INT2619

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Context Info
Confidence 0.49
First Reported 1979
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.97
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (TGM1) transferase activity, transferring acyl groups (TGM1)
Anatomy Link Frequency
epithelial cell 1
smooth muscle cells 1
TGM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 2 99.28 Very High Very High Very High
Pain 15 98.86 Very High Very High Very High
fluoxetine 2 77.96 Quite High
aspirin 88 76.08 Quite High
Inflammation 19 61.44 Quite High
palliative 1 50.72 Quite High
Inflammatory response 3 25.48 Quite Low
ischemia 1 25.00 Low Low
cytokine 5 19.92 Low Low
cINOD 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 78 99.96 Very High Very High Very High
Apoptosis 21 99.36 Very High Very High Very High
Pain 12 98.86 Very High Very High Very High
Death 2 98.16 Very High Very High Very High
Chronic Hepatitis 7 97.94 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 153 93.48 High High
Cirrhosis 2 80.76 Quite High
Autoimmune Disease 12 79.68 Quite High
Celiac Disease 2 77.36 Quite High
Disease 8 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction and activation of TGase is part of the apoptotic cascade and plays an effector role in the stabilization of apoptotic bodies to limit the leakage of intracellular components into the extracellular space (24).
Positive_regulation (induction) of TGase associated with apoptosis
1) Confidence 0.49 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729943 Disease Relevance 1.13 Pain Relevance 0.16
The induction and activation of TGase is part of the apoptotic cascade and plays an effector role in the stabilization of apoptotic bodies to limit the leakage of intracellular components into the extracellular space (24).
Positive_regulation (activation) of TGase associated with apoptosis
2) Confidence 0.33 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729943 Disease Relevance 1.13 Pain Relevance 0.16
The reduction in the inhibitory activity of LiJ in the presence of SP is mostly linked to its buffering capacity, suggesting that the main antiviral activity of LiJ is mediated by low pH.
Positive_regulation (mediated) of LiJ
3) Confidence 0.26 Published 2008 Journal Retrovirology Section Body Doc Link PMC2259360 Disease Relevance 0.64 Pain Relevance 0.07
Cervicovaginal epithelial cell monolayers were highly susceptible to LiJ induced toxicity.
Positive_regulation (induced) of LiJ in epithelial cell associated with toxicity
4) Confidence 0.23 Published 2008 Journal Retrovirology Section Body Doc Link PMC2259360 Disease Relevance 0.55 Pain Relevance 0.06
This effect was more noticeable with lower concentrations of LiJ, with the virucidal activity of ?
Positive_regulation (concentrations) of LiJ
5) Confidence 0.23 Published 2008 Journal Retrovirology Section Body Doc Link PMC2259360 Disease Relevance 0.40 Pain Relevance 0
One type of transglutaminase is usually accumulated in various forms of naturally occurring cell death and apoptosis.
Positive_regulation (accumulated) of transglutaminase associated with apoptosis and death
6) Confidence 0.08 Published 1998 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 9876874 Disease Relevance 0.51 Pain Relevance 0.05
Regarding the grade distribution patterns of P-p pain at the Li-8, LI-4, LI-11, and SI-11 loci, patients with chronic hepatitis showed a pattern of higher grades of P-p pain reactivity at the right Li-8 and SI-11 loci, and at the left LI-4 and LI-11 loci, while patients with the so-called female neurovegetative disorder, pregnant women, and patients affected with steroid side-effects showed a perfectly reversed reactivity pattern.
Positive_regulation (left) of LI-11 associated with pain and chronic hepatitis
7) Confidence 0.01 Published 1979 Journal Am. J. Chin. Med. Section Abstract Doc Link 484538 Disease Relevance 1.60 Pain Relevance 0.68
Transglutaminase-dependent RhoA activation and depletion by serotonin in vascular smooth muscle cells.
Positive_regulation (activation) of Transglutaminase in smooth muscle cells associated with serotonin
8) Confidence 0.01 Published 2007 Journal J. Biol. Chem. Section Title Doc Link 17142836 Disease Relevance 0 Pain Relevance 0.24

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