INT262148

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.69
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1b) mitochondrion (Abcb1b) ATPase activity (Abcb1b)
nucleus (Nr1i2) DNA binding (Nr1i2) transmembrane transport (Abcb1b)
Nr1i2 (Mus musculus)
Abcb1b (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 2 73.08 Quite High
Taxol 2 68.68 Quite High
Analgesic 1 51.04 Quite High
palliative 1 49.20 Quite Low
Bile 39 5.00 Very Low Very Low Very Low
Inflammation 17 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 5 100.00 Very High Very High Very High
Cancer 18 97.48 Very High Very High Very High
Endometriosis (extended) 3 89.20 High High
Apoptosis 5 66.48 Quite High
Breast Cancer 8 63.24 Quite High
Hypersensitivity 1 54.52 Quite High
Vomiting 1 50.56 Quite High
Inflammatory Bowel Disease 32 17.64 Low Low
Targeted Disruption 17 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, the work done by Baker and coworkers shows that activation of SXR by anti-neoplastic agents in osteosarcoma cell lines induces activity of CYP3A4 and MDR1, which provides a possible mechanism for drug resistance in these cells [Mensah-Osman et al., 2007].
Positive_regulation (activation) of SXR Positive_regulation (induces) of MDR1 associated with osteogenic sarcomas
1) Confidence 0.09 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.69 Pain Relevance 0.12

General Comments

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