INT262151

Context Info Confidence 0.24 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.24 Pain Relevance 0.23

cytosol (Vdr) mitochondrion (Cyp24a1) oxidoreductase activity (Cyp24a1) cell morphogenesis (Vdr) nucleus (Vdr) DNA binding (Vdr)

Anatomy Link Frequency kidney 1 Vdr (Mus musculus) Cyp24a1 (Mus musculus)

Pain Link Frequency Relevance Heat Bile 39 73.36 antiepileptic Drug 1 72.72 carbamazepine 1 67.92 agonist 9 51.76 Inflammation 17 5.00 antagonist 7 5.00 Crohn's disease 6 5.00 antidepressant 3 5.00 dexamethasone 2 5.00 Taxol 2 5.00

Disease Link Frequency Relevance Heat Toxicity 4 67.36 Metabolic Bone Disease 1 62.08 Rickets 8 60.08 Targeted Disruption 17 55.44 Inflammatory Bowel Disease 32 5.00 Cancer 18 5.00 INFLAMMATION 12 5.00 Disease 10 5.00 Breast Cancer 8 5.00 Osteoporosis 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CYP24 is directly regulated by VDR and it is expressed mainly in the kidney where VDR is also abundant.

VDR Regulation (regulated) of CYP24 in kidney

1) Confidence 0.24 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.24 Pain Relevance 0.23

General Comments

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