INT26218

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Context Info
Confidence 0.02
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.26
Pain Relevance 4.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Gt(pU21)50Imeg (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 5 100.00 Very High Very High Very High
intrathecal 2 100.00 Very High Very High Very High
antinociception 11 99.98 Very High Very High Very High
Antinociceptive 7 99.98 Very High Very High Very High
Enkephalin 4 99.60 Very High Very High Very High
Analgesic 2 99.60 Very High Very High Very High
Oxycodone 8 99.56 Very High Very High Very High
Opioid 7 98.16 Very High Very High Very High
Kappa opioid receptor 4 95.60 Very High Very High Very High
Calcitonin gene-related peptide 10 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1 87.12 High High
Disease 2 85.88 High High
INFLAMMATION 2 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with U50,488 significantly reduced LPS-stimulated interleukin-6 (IL-6) production as measured by ELISA.
Gene_expression (production) of U50
1) Confidence 0.02 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16644488 Disease Relevance 0.26 Pain Relevance 0.80
The antinociception produced by intrathecal morphine, calcium, A23187, U50,488H, [D-Ala2, N-Me-Phe4, Gly-ol]enkephalin and [D-Pen2, D-Pen5]enkephalin after intrathecal administration of calcitonin gene-related peptide in mice.
Gene_expression (produced) of U50 associated with antinociception, analgesic, enkephalin, calcitonin gene-related peptide, morphine and intrathecal
2) Confidence 0.02 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 2552070 Disease Relevance 0 Pain Relevance 1.51
Antinociceptive response of DAMGO, SNC80, U50,488H, and oxycodone in tolerant mice treated with BMS182874 was significantly higher (44.55%, 37.48%, 43.02%, and 56.08%, respectively) compared to tolerant mice treated with vehicle.
Gene_expression (response) of U50 associated with oxycodone and antinociceptive
3) Confidence 0.01 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20303944 Disease Relevance 0 Pain Relevance 2.32

General Comments

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