INT262199

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.15 Pain Relevance 0

oxidoreductase activity (Cyp2b9)

Anatomy Link Frequency CAR 1 Cyp2b9 (Mus musculus) Rare1 (Mus musculus)

Pain Link Frequency Relevance Heat Bile 39 49.72 Inflammation 17 5.00 agonist 9 5.00 antagonist 7 5.00 Crohn's disease 6 5.00 antidepressant 3 5.00 dexamethasone 2 5.00 Taxol 2 5.00 palliative 1 5.00 carbamazepine 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 17 83.28 Increased Venous Pressure Under Development 1 24.64 Hyperlipidemia 3 23.84 Inflammatory Bowel Disease 32 5.00 Cancer 18 5.00 INFLAMMATION 12 5.00 Disease 10 5.00 Rickets 8 5.00 Breast Cancer 8 5.00 Osteoporosis 7 5.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

CAR can regulate CYP3A genes through SXR response elements and SXR can regulate CYP2B genes via adaptive recognition of the phenobarbital response element (PBRE), as revealed by receptor-DNA binding analysis and transfection assays [Xie et al., 2000b].

CYP2B Binding (recognition) of phenobarbital response element in CAR

1) Confidence 0.01 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.15 Pain Relevance 0

General Comments

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