INT262208

Context Info Confidence 0.09 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.59 Pain Relevance 0.29

nucleus (Nr1i2) DNA binding (Nr1i2)

Anatomy Link Frequency bile 1 Clta (Mus musculus) Nr1i2 (Mus musculus)

Pain Link Frequency Relevance Heat Bile 39 98.58 Inflammation 17 5.00 agonist 9 5.00 antagonist 7 5.00 Crohn's disease 6 5.00 antidepressant 3 5.00 dexamethasone 2 5.00 Taxol 2 5.00 palliative 1 5.00 carbamazepine 1 5.00

Disease Link Frequency Relevance Heat Colon Cancer 2 94.52 Liver Disease 1 93.84 Hepatotoxicity 2 88.72 Osteoporosis 7 75.72 Toxicity 4 64.64 Targeted Disruption 17 56.64 Inflammatory Bowel Disease 32 5.00 Cancer 18 5.00 INFLAMMATION 12 5.00 Disease 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

An intriguing link between SXR and bile acid homeostasis was uncovered by the discovery that the highly toxic LCA and its 3-keto metabolite can efficiently activate SXR [Staudinger et al., 2001; Xie et al., 2001].

LCA Positive_regulation (activate) of SXR in bile associated with bile

1) Confidence 0.09 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.59 Pain Relevance 0.29

General Comments

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