INT262398

Context Info Confidence 0.34 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.77 Pain Relevance 0

mitochondrion (Peo1) helicase activity (Peo1)

Anatomy Link Frequency blood 1 Peo1 (Mus musculus)

Pain Link Frequency Relevance Heat imagery 3 5.00 isoflurane 2 5.00 anesthesia 1 5.00 Potency 1 5.00

Disease Link Frequency Relevance Heat Cancer 116 94.88 Adenocarcinoma 26 93.04 Breast Cancer 2 50.00 Apoptosis 11 5.00 Death 6 5.00 Toxicity 3 5.00 Ovarian Cancer 3 5.00 Peripheral Arterial Disease 3 5.00 Solid Tumor 2 5.00 Weight Loss 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results are supportive of the known effects of PEO-surface modification on nanoparticles to produce prolonged circulation by stealth shielding, and agree well with the blood and tumor pharmacokinetic profile determined for PTX from free drug administration and nanoparticle delivery in SKOV3 tumor bearing mice.15

Localization (effects) of PEO in blood associated with cancer

1) Confidence 0.34 Published 2008 Journal Molecular Pharmaceutics Section Body Doc Link PMC2646668 Disease Relevance 0.77 Pain Relevance 0

General Comments

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