INT262580

Context Info Confidence 0.03 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.35 Pain Relevance 0.72

extracellular space (Ngf, Hspg2) extracellular region (Ngf, Hspg2) signal transduction (Ngf) proteinaceous extracellular matrix (Hspg2) extracellular matrix organization (Hspg2)

Ngf (Mus musculus) Hspg2 (Mus musculus)

Pain Link Frequency Relevance Heat Nerve growth factor 8 100.00 Lasting pain 7 99.92 qutenza 74 95.20 Cancer pain 1 93.08 antagonist 31 89.32 Pain 30 63.36 Osteoarthritis 1 48.16 substance P 11 47.76 allodynia 1 47.40 calcitonin gene related peptide 14 47.20

Disease Link Frequency Relevance Heat Pain 38 99.92 Cancer Pain 1 93.08 Bone Cancer 1 92.88 Osteoarthritis 1 48.16 Neuropathic Pain 6 47.40 Nociception 16 41.04 Coronary Artery Disease 2 22.00 Diabetes Mellitus 6 5.52 INFLAMMATION 21 5.00 Targeted Disruption 12 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

NGF has been shown to sensitize TRPV1 by activating PLC and hydrolyzes PIP2, which tonically inhibits the channel [35, 139], or by activating PKC, PI3K [26, 35, 161, 167] and ERK [204].

NGF Positive_regulation (activating) of PLC associated with nerve growth factor

1) Confidence 0.03 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.35 Pain Relevance 0.72

General Comments

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