INT262858

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.54
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Defa1) extracellular region (Defa1)
Anatomy Link Frequency
dendritic cells 1
T-cells 1
Defa1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 45 88.24 High High
Inflammation 32 71.76 Quite High
psoriasis 100 70.28 Quite High
Crohn's disease 4 62.88 Quite High
Arthritis 2 17.28 Low Low
rheumatoid arthritis 20 16.32 Low Low
Bile 6 5.00 Very Low Very Low Very Low
spastic colon 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 44 85.68 High High
Psoriasis 138 80.16 Quite High
INFLAMMATION 31 71.76 Quite High
Eczema 38 71.40 Quite High
Disease 111 69.84 Quite High
Celiac Disease 2 60.88 Quite High
Infection 29 19.28 Low Low
Seronegative Spondarthritis 2 17.28 Low Low
Rheumatoid Arthritis 20 16.32 Low Low
Diarrhoea 39 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several studies have demonstrated the biological activities of human and mouse beta-defensins, such as antimicrobial activity [9], chemotaxis of T-cells and dendritic cells [44], and activation of TLR4 [45].
Positive_regulation (activation) of defensin in dendritic cells
1) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.67 Pain Relevance 0.42
Several studies have demonstrated the biological activities of human and mouse beta-defensins, such as antimicrobial activity [9], chemotaxis of T-cells and dendritic cells [44], and activation of TLR4 [45].
Positive_regulation (activation) of defensin in T-cells
2) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.67 Pain Relevance 0.42
is the activation of the murine defensin cryptdin (an alpha-defensin that is
Positive_regulation (activation) of defensin
3) Confidence 0.01 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648624 Disease Relevance 0.20 Pain Relevance 0.06

General Comments

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