INT262878

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 12
Disease Relevance 4.70
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (ST8SIA2) Golgi apparatus (ST8SIA2) carbohydrate metabolic process (ST8SIA2)
ST8SIA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 162 99.90 Very High Very High Very High
Bile 30 54.36 Quite High
local anesthetic 13 50.72 Quite High
sodium channel 9 37.68 Quite Low
addiction 28 28.88 Quite Low
Action potential 3 21.24 Low Low
cytokine 28 5.00 Very Low Very Low Very Low
Piles 24 5.00 Very Low Very Low Very Low
Inflammation 22 5.00 Very Low Very Low Very Low
headache 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 194 98.96 Very High Very High Very High
Hemolytic Uremic Syndrome 32 95.76 Very High Very High Very High
Disease 142 94.40 High High
Renal Failure 4 90.40 High High
Infection 100 90.08 High High
Diarrhoea 156 83.20 Quite High
Shellfish Poisoning 66 82.92 Quite High
Death 17 79.76 Quite High
Colitis 24 77.48 Quite High
Toxicity 72 66.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
He confirmed that TTX and STX appeared to be completely specific for Na channels and bound with 1:1 stoichiometry.
Gene_expression (specific) of STX associated with tetrodotoxin
1) Confidence 0.39 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2852835 Disease Relevance 0 Pain Relevance 0.48
The requirement of SAM for STX biosynthesis has long been hypothesized and thus has been targeted during attempts to identify the PST genes [137,138].
Gene_expression (biosynthesis) of STX
2) Confidence 0.16 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.07 Pain Relevance 0
Proteomic and transcriptomic studies are likely to provide a link between STX biosynthesis, regulation and cellular metabolism.
Gene_expression (biosynthesis) of STX
3) Confidence 0.16 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.05 Pain Relevance 0
The saxitoxin biosynthetic gene cluster (sxt) was recently identified in cyanobacteria, which now provides insight into the biosynthesis of STX and its analogs [33,34].
Gene_expression (biosynthesis) of STX
4) Confidence 0.16 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.42 Pain Relevance 0.05
The core PST biosynthetic gene, sxtA, is thought to have a chimeric origin and is putatively responsible for the initiation of STX biosynthesis, catalysing the incorporation of acetate to the enzyme complex and its subsequent methylation and Claisen condensation with arginine [33,34,129].
Gene_expression (biosynthesis) of STX
5) Confidence 0.13 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0 Pain Relevance 0
The sxt gene clusters within each organism all contain a core set of genes putatively responsible for the biosynthesis of STX.
Gene_expression (biosynthesis) of STX
6) Confidence 0.13 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.14 Pain Relevance 0
In cyanobacteria, biosynthesis of STX is catalyzed by several enzymes otherwise rare in microbial metabolism.
Gene_expression (biosynthesis) of STX
7) Confidence 0.13 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.06 Pain Relevance 0
Within the framework of their model STX exhibited shorter on-rates and off-rates than TTX.
Gene_expression (exhibited) of STX associated with tetrodotoxin
8) Confidence 0.06 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866490 Disease Relevance 0 Pain Relevance 0.45
generated “designer probiotics” in which the oligosaccharide receptor (Gb3) for Stx is expressed on the cell surface of
Gene_expression (expressed) of Stx
9) Confidence 0.06 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648624 Disease Relevance 1.17 Pain Relevance 0
characterized by the expression of Shiga toxin (Stx) genes, and thus they can
Gene_expression (expression) of Stx
10) Confidence 0.06 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648624 Disease Relevance 1.18 Pain Relevance 0.03
generated “designer probiotics” in which the oligosaccharide receptor (Gb3) for Stx is expressed on the cell surface of
Gene_expression (expressed) of Stx
11) Confidence 0.05 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648624 Disease Relevance 1.17 Pain Relevance 0
that phage activation and cell lysis are responsible for Stx production and
Gene_expression (production) of Stx
12) Confidence 0.04 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648624 Disease Relevance 0.44 Pain Relevance 0

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