INT2630

Context Info Confidence 0.70 First Reported 1979 Last Reported 2010 Negated 3 Speculated 0 Reported most in Body Documents 134 Total Number 139 Disease Relevance 65.26 Pain Relevance 15.19

extracellular space (Shbg) extracellular region (Shbg)

Anatomy Link Frequency blood 11 follicle 3 superior 3 sympathetic 3 heart 3 Shbg (Rattus norvegicus)

Pain Link Frequency Relevance Heat headache 238 99.84 Morphine 7 99.84 Catecholamine 28 99.74 withdrawal 125 99.48 Intracerebroventricular 1 99.36 Pain 203 98.88 isoflurane 14 98.52 antagonist 145 97.08 Opioid 15 96.88 Snapping jaw 8 96.16

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 250 100.00 Peritonitis 161 100.00 Hypertension 1909 99.98 Stress 342 99.84 Headache 306 99.84 Increased Venous Pressure Under Development 50 99.80 Bradycardia 36 99.76 Emergencies 55 99.72 Chronic Renal Insufficiency 8 99.66 Cancer 381 99.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This causes their plasma concentrations to increase with time, since SHBG is induced by ethinylestradiol even in doses of 30 micrograms daily.

Positive_regulation (induced) of SHBG in plasma

1) Confidence 0.70 Published 1991 Journal Clin Pharmacokinet Section Abstract Doc Link 2029800 Disease Relevance 0 Pain Relevance 0.08

The pretreatment of NG-monomethyl-L-arginine dose-dependently reduced the elevation of ABP but did not completely abolish it.

Positive_regulation (elevation) of ABP

2) Confidence 0.69 Published 1995 Journal Artif Organs Section Abstract Doc Link 7763190 Disease Relevance 0 Pain Relevance 0

Results indicate that inhibition of nitric oxide (NO) might be responsible in part for the elevation of ABP, and the degree of the elevation would be dependent on the degree of contribution of NO to the regulation of ABP.

Positive_regulation (elevation) of ABP

3) Confidence 0.69 Published 1995 Journal Artif Organs Section Abstract Doc Link 7763190 Disease Relevance 0 Pain Relevance 0

Pretreatment with various blockers did not abolish the elevation of ABP.

Positive_regulation (elevation) of ABP

4) Confidence 0.69 Published 1995 Journal Artif Organs Section Abstract Doc Link 7763190 Disease Relevance 0 Pain Relevance 0

SHBG concentrations were elevated in the Large-tumor group.

Positive_regulation (elevated) of SHBG associated with cancer

5) Confidence 0.67 Published 1986 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 3799148 Disease Relevance 0.90 Pain Relevance 0.07

Administration of both drugs produced a significant suppression of elevation of SBP, and produced a significant elevation of pain sensitivity.

Positive_regulation (elevation) of SBP associated with pain

6) Confidence 0.66 Published 1991 Journal Nippon Jinzo Gakkai Shi Section Abstract Doc Link 1808360 Disease Relevance 1.01 Pain Relevance 0.75

Levels of sex hormone binding globulin (SHBG), a protein increased by EE to which NET binds, were also examined.

Positive_regulation (increased) of SHBG

7) Confidence 0.66 Published 2000 Journal J Clin Pharmacol Section Abstract Doc Link 10709161 Disease Relevance 0.09 Pain Relevance 0.17

In both phase I and II studies arzoxifene showed similar endocrine effects of decreasing FSH and LH levels with increasing SHBG levels as had been reported with tamoxifen (Lønning et al. 1995; Kostoglou-Athanassiou et al. 1997).

Positive_regulation (increasing) of SHBG

8) Confidence 0.52 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012444 Disease Relevance 0.55 Pain Relevance 0.08

Although interpretation was limited by the small sample size, arzoxifene appeared to lower proliferation markers including proliferating cell nuclear antigen (PCNA), insulin-like growth factor (IGF)-1 and IGF-binding protein-3 (IGFBP-3), decrease estrogen expression and LH levels, and increase SHBG levels.

Positive_regulation (increase) of SHBG

9) Confidence 0.52 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012444 Disease Relevance 1.08 Pain Relevance 0.13

There was a significant decrease in follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels, along with an increase in sex hormone-binding globulin (SHBG).

Positive_regulation (increase) of SHBG in follicle

10) Confidence 0.52 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012444 Disease Relevance 0.77 Pain Relevance 0.06

This increase in SHBG could be interpreted as a marker of improved insulin sensitivity, nicely fitting the finding of improved glycemic control in the paroxetine group.

Positive_regulation (increase) of SHBG

11) Confidence 0.51 Published 2003 Journal BMC Fam Pract Section Body Doc Link PMC165418 Disease Relevance 0.25 Pain Relevance 0

In the paroxetine group a superior increase in SHBG levels were observed.

Positive_regulation (increase) of SHBG in superior

12) Confidence 0.51 Published 2003 Journal BMC Fam Pract Section Body Doc Link PMC165418 Disease Relevance 0.25 Pain Relevance 0

The patients had higher levels of testosterone and SHBG than did the controls (p = 0.04 and p = 0.03, respectively).

Positive_regulation (levels) of SHBG

13) Confidence 0.50 Published 2008 Journal Digestion Section Body Doc Link 18974649 Disease Relevance 0 Pain Relevance 0

Patients with advanced liver disease and low ascitic fluid protein concentrations seem to have an increased susceptibility to SBP.

Positive_regulation (increased) of SBP in liver associated with liver disease

14) Confidence 0.50 Published 1992 Journal Gastroenterol. Clin. North Am. Section Abstract Doc Link 1568776 Disease Relevance 1.05 Pain Relevance 0.09

The maximal response of SBP to phenylephrine or sodium nitroprusside and the corresponding maximal reflex change in pulse interval were plotted for each drug.

Positive_regulation (response) of SBP

15) Confidence 0.48 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3004820 Disease Relevance 0.05 Pain Relevance 0.09

Moreover, regitine was shown to inhibit the increase of mABP in morphine withdrawal rats, but can not inhibit the increase of HR.

Positive_regulation (increase) of mABP associated with withdrawal and morphine

16) Confidence 0.46 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016923 Disease Relevance 0.27 Pain Relevance 0.74

There was a significant decrease in follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels, along with an increase in sex hormone-binding globulin (SHBG).

Positive_regulation (increase) of hormone-binding globulin in follicle

17) Confidence 0.45 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012444 Disease Relevance 0.76 Pain Relevance 0.06

The LF component of SBP (SBP-LF) increases in conditions associated with various sympathetic activations [13-15].

Positive_regulation (increases) of SBP in sympathetic

18) Confidence 0.45 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3004820 Disease Relevance 0.82 Pain Relevance 0.14

The LF component of SBP (SBP-LF) increases in conditions associated with various sympathetic activations [13-15].

Positive_regulation (increases) of SBP-LF in sympathetic

19) Confidence 0.45 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3004820 Disease Relevance 0.77 Pain Relevance 0.14

In the presence of atenolol 2 mg kg(-1) h(-1), clonidine 10-100 microg kg(-1) i.v. evoked a significant reduction in SBP, a large increase of CVM firing rate from a very low base line [0.16 (sd 0.28) to 1.37 (1.21) spikes s(-1), n=7 cells], and increased the slope of the cardiac baroreflex analysed at the CVM level or at the heart level. sds of SBP were reduced, and that of RR interval was increased.

Positive_regulation (increase) of SBP in spikes

20) Confidence 0.44 Published 2009 Journal Br J Anaesth Section Body Doc Link 19189981 Disease Relevance 0.07 Pain Relevance 0

General Comments

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