INT26313

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Context Info
Confidence 0.53
First Reported 1989
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP3) extracellular space (MMP3) extracellular region (MMP3)
proteinaceous extracellular matrix (MMP3) nucleus (MMP3) protein complex (MMP3)
MMP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1 96.64 Very High Very High Very High
cINOD 1 83.36 Quite High
spinal inflammation 2 50.00 Quite Low
antagonist 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Osteoarthritis 4 89.56 High High
Low Back Pain 2 50.00 Quite Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tiaprofenic acid induced in vitro a concomitant increase in PLA2 and a decrease in proteoglycanase activity.
Positive_regulation (increase) of Negative_regulation (decrease) of proteoglycanase
1) Confidence 0.53 Published 1989 Journal J Rheumatol Suppl Section Abstract Doc Link 2553968 Disease Relevance 0.33 Pain Relevance 0.13
TNFalpha antagonist therapy induces a significant decrease in MMP-3 levels, together with decreases in conventional variables (ESR, CRP, and BASDAI).
Positive_regulation (induces) of Negative_regulation (decrease) of MMP-3
2) Confidence 0.40 Published 2008 Journal Joint Bone Spine Section Body Doc Link 18674944 Disease Relevance 0 Pain Relevance 0

General Comments

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