INT26314

Context Info Confidence 0.67 First Reported 1989 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 48 Total Number 48 Disease Relevance 22.14 Pain Relevance 16.17

peptidase activity (MMP3) extracellular space (MMP3) extracellular region (MMP3) proteinaceous extracellular matrix (MMP3) nucleus (MMP3) protein complex (MMP3)

Anatomy Link Frequency chondrocytes 2 synovial fluid 2 cartilage 2 articular cartilage 2 joint 2 MMP3 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 1125 100.00 Inflammation 357 100.00 rheumatoid arthritis 358 99.84 endometriosis 92 99.20 Osteoarthritis 598 98.62 cINOD 45 97.86 cytokine 243 97.70 imagery 23 93.36 Kinase C 3 91.32 Snapping jaw 10 90.56

Disease Link Frequency Relevance Heat INFLAMMATION 414 100.00 Rheumatoid Arthritis 366 99.84 Polymyalgia Rheumatica 9 99.84 Bladder Cancer 116 99.48 Endometriosis 131 99.20 Transitional Cell Carcinoma 104 98.92 Synovitis 17 98.84 Injury 254 98.80 Osteoarthritis 238 98.62 Cancer 290 98.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Serum matrix metalloproteinase-3, a parameter of synovial inflammation, was significantly increased in PMR patients.

Positive_regulation (increased) of matrix metalloproteinase-3 associated with polymyalgia rheumatica, inflammation and metalloproteinase

1) Confidence 0.67 Published 2007 Journal Mod Rheumatol Section Abstract Doc Link 17929127 Disease Relevance 2.06 Pain Relevance 0.51

The increased protein levels of MMP-1 and MMP-3 were also reduced by 1000 microg/ml HA.

Positive_regulation (increased) of MMP-3 associated with metalloproteinase

2) Confidence 0.61 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15383690 Disease Relevance 0.20 Pain Relevance 0.89

Spontaneous parturition at term and preterm is associated with significant increase in amniotic fluid concentrations of MMP-3, but not MMP-1 (Maymon et al., 2000; Park et al., 2003).

Positive_regulation (increase) of MMP-3 in amniotic fluid associated with metalloproteinase

3) Confidence 0.60 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0.08 Pain Relevance 0.60

Prostaglandin E2, for instance, induces activation of MMP-3, but does not affect MMP-3 total protein in the rat cervix (Chien et al., 2005).

Positive_regulation (activation) of MMP-3 in cervix associated with metalloproteinase

4) Confidence 0.60 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0.05 Pain Relevance 0.19

Activated MMP1, MMP3 and latent forms of MMP2 and MMP9 are regulated and inhibited by endogenous proteins known as tissue inhibitors of metalloproteinase TIMP1 and TIMP2 [17].

Positive_regulation (Activated) of MMP3 associated with metalloproteinase

5) Confidence 0.59 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.87 Pain Relevance 0.23

They found elevated concentrations of MMP2 and MMP3 in patients with advanced TCC of the bladder (pT2-T4, N+, M+) in comparison to the serum of patients with superficial tumors (Ta-T1, N0, M0).

Positive_regulation (elevated) of MMP3 in bladder associated with cancer and transitional cell carcinoma

6) Confidence 0.59 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 1.11 Pain Relevance 0.12

Activated MMP1, MMP3, and latent forms of MMP2 and MMP9 bind to and are inhibited by TIMP1 and TIMP2.

Positive_regulation (Activated) of MMP3

7) Confidence 0.59 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.68 Pain Relevance 0.51

CONCLUSION: MMP-3 is significantly increased in patients with active AS but fails to correlate significantly with conventional variables used to assess disease activity.

Neg (fails) Positive_regulation (increased) of MMP-3

8) Confidence 0.48 Published 2008 Journal Joint Bone Spine Section Body Doc Link 18674944 Disease Relevance 0 Pain Relevance 0

The MMP-3 level in the placebo group remained virtually unchanged at day 90 compared with baseline.

Positive_regulation (unchanged) of MMP-3

9) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575633 Disease Relevance 0.10 Pain Relevance 0.05

One patient with septic arthritis showed a fivefold peak increase in joint fluid aggrecan fragment concentrations, while the concentration of matrix metalloproteinase-3 increased 100-fold.

Positive_regulation (increased) of matrix metalloproteinase-3 in joint

10) Confidence 0.45 Published 1998 Journal Osteoarthr. Cartil. Section Body Doc Link 10197170 Disease Relevance 0 Pain Relevance 0

Their studies revealed further elevated MMP2, MMP3, and TIMP2 concentrations from patients after tumour resection, which might function as a predictive value for early detection of tumour recurrence [20,40].

Positive_regulation (elevated) of MMP3 associated with cancer and recurrence

11) Confidence 0.43 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 1.13 Pain Relevance 0.17

However, changes in both MMP3 and MMP13 gene expression are rapid, dramatic, sustained, and changing during at least the first 48 h of unloaded culture.

Positive_regulation (changes) of MMP3

12) Confidence 0.42 Published 2008 Journal J. Orthop. Res. Section Abstract Doc Link 18404723 Disease Relevance 0.36 Pain Relevance 0.10

However, cytokines are known to stimulate the production of MMPs (Ito et al., 1991; Imada et al., 1997a, b; Oner et al., 2008), so it would be logical to expect an elevation of MMP-1 and MMP-3 levels when there is an increased secretion of IL-8.

Positive_regulation (elevation) of MMP-3 associated with metalloproteinase and cytokine

13) Confidence 0.40 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0 Pain Relevance 0.41

Nimesulide significantly reduced the serum levels of both HA and MMP-3, whereas ibuprofen increased moderately but significantly the serum concentrations of MMP-3 and had no effect on the serum concentrations of HA.

Positive_regulation (increased) of MMP-3

14) Confidence 0.40 Published 2004 Journal Int J Clin Pract Suppl Section Abstract Doc Link 16035398 Disease Relevance 0.32 Pain Relevance 0.46

These cytokines act in various ways in the pathogenesis of OA such as inhibition of synthesis of type 2 (articular) cartilage and activation of catabolic metalloproteases including MMP-3 which plays a critical role in cartilage degradation 44,45.

Positive_regulation (activation) of MMP-3 in cartilage associated with osteoarthritis and cytokine

15) Confidence 0.38 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2974165 Disease Relevance 1.27 Pain Relevance 0.93

Serum MMP-3 levels were significantly higher in the patients than in the controls (4.71 vs. 2.79 ng/ml, P=0.04); levels were also higher for cathepsin K (6.4 vs. 3.6 pg/ml) and IL-17 (60.4 vs. 32 pg/ml), but the differences were not statistically significant.

Positive_regulation (higher) of MMP-3

16) Confidence 0.37 Published 2008 Journal Joint Bone Spine Section Body Doc Link 18674944 Disease Relevance 0 Pain Relevance 0

In the present study, supernatant MMP levels did not demonstrate any significant differences in response to PHT and HPPH alone at either dose compared to untreated macrophage cultures although we noted a trend for higher levels of MMP-1 and MMP-3.

Positive_regulation (levels) of MMP-3 in macrophage

17) Confidence 0.37 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.29 Pain Relevance 0

increased mRNAs for catabolic factors MMP-1 and MMP-3.

Positive_regulation (increased) of MMP-3

18) Confidence 0.35 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 20839316 Disease Relevance 0.34 Pain Relevance 0.44

Tiaprofenic acid induced in vitro a concomitant increase in PLA2 and a decrease in proteoglycanase activity.

Positive_regulation (increase) of proteoglycanase

19) Confidence 0.35 Published 1989 Journal J Rheumatol Suppl Section Abstract Doc Link 2553968 Disease Relevance 0.33 Pain Relevance 0.13

One interesting finding of this study is that preterm and term cervical fibroblasts show different secretion patterns of IL-8, MMP-1 and MMP-3, where IL-8 and MMP-1 are secreted at higher levels in preterm and MMP-3 in term cervical fibroblasts.

Positive_regulation (levels) of MMP-3 in fibroblasts associated with metalloproteinase

20) Confidence 0.35 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0 Pain Relevance 0.43

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