INT26317

Context Info Confidence 0.45 First Reported 1989 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 2.97 Pain Relevance 1.96

cytosol (NFKBIA) plasma membrane (NFKBIA) nucleus (NFKBIA) enzyme binding (NFKBIA) transcription factor binding (NFKBIA) cytoplasm (NFKBIA)

Anatomy Link Frequency B cell 1 platelet 1 NFKBIA (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 229 99.36 cytokine 54 98.88 aspirin 11 97.54 fibrosis 3 97.48 Chronic pancreatitis 7 96.64 Pain 4 94.36 corticosteroid 112 94.00 COX-2 inhibitor 2 78.92 cINOD 6 77.08 vincristine 1 59.56

Disease Link Frequency Relevance Heat INFLAMMATION 377 99.36 Leukemia 5 98.76 Fibrosis 4 97.48 Pancreatitis 7 96.64 Fever 2 95.20 Arthralgia 1 94.60 Apoptosis 16 92.28 Lymphadenopathy 1 91.72 Hepatomegaly 1 90.92 Death 12 87.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The NFkappaB regulated proteins IkappaBalpha, survivin, and cIAP1 were found in corresponding sites, again, at highest levels in islets surrounded by fibrosis.

Gene_expression (found) of IkappaBalpha associated with fibrosis

1) Confidence 0.45 Published 2006 Journal Verh Dtsch Ges Pathol Section Abstract Doc Link 17867593 Disease Relevance 1.15 Pain Relevance 0.59

The dynamics of the gene transcript of IKBa (mRNA,IKBa), (2c), are characterized by a zero order production rate (Kin,IkBa) and a first order degradation rate (Kout,IkBa) which is stimulated by NFkB [36].

Gene_expression (production) of IkBa

2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.18 Pain Relevance 0.09

IkBa, IL-10; (ii) or increased expression of an inhibitor to phospholipase A2 (annexin I) which subsequently leads to reduced formation of both arachidonic acid and platelet-activating factor as well as (ii) a disruption of the basal transcriptional machinery that inhibits the transcriptional activity of NFkB.

Gene_expression (expression) of IkBa in platelet

3) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.34 Pain Relevance 0.47

Inhibition of nuclear factor-kappaB activation or disruption of IL-6-mediated signaling through the expression of IkappaBalpha S32AS36A and suppressor of cytokine signaling 3, respectively, blocks Rac1-induced STAT3 activation.

Gene_expression (expression) of IkappaBalpha associated with cytokine

4) Confidence 0.20 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.05 Pain Relevance 0.05

Data of Western blot further demonstrated that aspirin treatment caused activation of caspases, down-regulation of Mcl-1 protein, dephosphorylation of ERK-1/2 and AKT, and also IkappaB-alpha proteolysis-dependent NF-kappaB activation in YD-8 cells.

Gene_expression (proteolysis) of IkappaB-alpha associated with aspirin

5) Confidence 0.07 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.63 Pain Relevance 0.64

[Germ-line configuration of the immunoglobulin heavy chain gene in a case of B cell precursor acute lymphoblastic leukemia].

Gene_expression (configuration) of chain gene in B cell associated with leukemia

6) Confidence 0.02 Published 1989 Journal Rinsho Ketsueki Section Title Doc Link 2554012 Disease Relevance 0.62 Pain Relevance 0.12

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