INT263233

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.10
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2J2) endoplasmic reticulum (CYP2J2)
Anatomy Link Frequency
brain 1
CYP2J2 (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 2 95.92 Very High Very High Very High
spinal dorsal horn 19 93.84 High High
central sensitization 2 89.40 High High
Hyperalgesia 3 89.36 High High
Dorsal horn neuron 1 87.52 High High
antagonist 18 81.44 Quite High
Analgesic 1 67.44 Quite High
Pain 6 57.28 Quite High
Hippocampus 5 57.12 Quite High
TRP channel 6 56.80 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 3 99.48 Very High Very High Very High
Brain Tumor 2 99.48 Very High Very High Very High
Carcinoma 6 99.32 Very High Very High Very High
Cancer 232 98.08 Very High Very High Very High
Disease 12 96.84 Very High Very High Very High
Prostate Cancer 14 92.84 High High
Diabetes Mellitus 2 91.00 High High
Hyperalgesia 5 89.36 High High
Lung Cancer 2 81.84 Quite High
Renal Cancer 2 77.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, CYP2J2 was upregulated in 77% of human carcinoma tissues and eight different human carcinoma cell lines [120].
Positive_regulation (upregulated) of CYP2J2 associated with carcinoma
1) Confidence 0.40 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.17 Pain Relevance 0.03
Another epoxygenase, CYP2C11, was shown by Zagorac et al. to be upregulated in cerebral brain tumors of rats [124].
Positive_regulation (upregulated) of epoxygenase in brain associated with brain tumor
2) Confidence 0.27 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.41 Pain Relevance 0.08
The endogenous ligand for TRPV4 may be EETs, generated from AA by cytochrome P450 epoxygenase activation during cell swelling [20].
Positive_regulation (activation) of cytochrome P450 epoxygenase associated with pressure and volume under development
3) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2650694 Disease Relevance 0.52 Pain Relevance 0.52

General Comments

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