INT263403

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 4.68
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Rock1) cytoskeleton (Rock1) cytoskeleton organization (Rock1)
cytoplasm (Rock1)
Anatomy Link Frequency
neurons 2
leukocyte 1
Rock1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 124 99.80 Very High Very High Very High
cva 20 96.52 Very High Very High Very High
ischemia 12 78.80 Quite High
long-term potentiation 20 75.00 Quite High
Hippocampus 16 59.12 Quite High
cytokine 4 52.72 Quite High
depression 32 52.56 Quite High
Dopamine 4 41.68 Quite Low
Pyramidal cell 8 5.00 Very Low Very Low Very Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetic Macular Edema 104 99.88 Very High Very High Very High
Diabetes Mellitus 68 99.30 Very High Very High Very High
Adhesions 44 99.06 Very High Very High Very High
Increased Venous Pressure Under Development 4 98.08 Very High Very High Very High
Neurological Disease 4 97.88 Very High Very High Very High
Cv General 3 Under Development 12 96.52 Very High Very High Very High
Hypertension 12 95.60 Very High Very High Very High
Targeted Disruption 8 94.80 High High
Proliferative Vitreoretinopathy 28 89.08 High High
Disease 8 88.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we revealed that Rho/ROCK pathway is activated in retinal microvessels during diabetes (Figures 1(a)–1(e)).
Positive_regulation (activated) of Rho/ROCK associated with diabetes mellitus
1) Confidence 0.38 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 1.00 Pain Relevance 0
Abnormal activation of the Rho/ROCK pathway is important in the pathogenesis of several neurological diseases [53].
Positive_regulation (activation) of Rho/ROCK associated with neurological disease
2) Confidence 0.35 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 1.11 Pain Relevance 0.16
Rho/ROCK activation plays an important role in the pathogenesis of vasoconstriction, such as cerebral and coronary spasm [47] or hypertension [48], by NO-dependent mechanisms.
Positive_regulation (activation) of Rho/ROCK associated with hypertension, cva and increased venous pressure under development
3) Confidence 0.35 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 1.10 Pain Relevance 0.08
Treatment with intravitreal injection of fasudil significantly decreased retinal leukocyte adhesion in diabetic rat mediated through reduction of ROCK activation.
Positive_regulation (activation) of ROCK in leukocyte associated with diabetes mellitus and adhesions
4) Confidence 0.35 Published 2010 Journal Journal of Ophthalmology Section Body Doc Link PMC2905943 Disease Relevance 1.17 Pain Relevance 0.07
These observations show that ROCK is required for Abl-mediated changes in the actin cytoskeleton that leads to inhibition of NMDA currents and that Abl-mediated inhibition of NMDA receptor currents requires RhoGTPase and ROCK signaling (Figure 5).
Positive_regulation (requires) of ROCK associated with nmda receptor
5) Confidence 0.11 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.25
In Abl and Abl-related gene (Arg) double-knock out mice, the extent of dendritic branching in substantially reduced [20] and treatment of developing cultured neurons with the Abl inhibitor, STI571, decreases the complexity of neuronal dendritic branching via an increase in RhoA activity [21] and possible activation of Rho-associated kinase (ROCK) [22-24].
Spec (possible) Positive_regulation (activation) of Rho-associated kinase in neurons associated with targeted disruption
6) Confidence 0.11 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.15 Pain Relevance 0.14
These observations show that ROCK is required for Abl-mediated changes in the actin cytoskeleton that leads to inhibition of NMDA currents and that Abl-mediated inhibition of NMDA receptor currents requires RhoGTPase and ROCK signaling (Figure 5).
Positive_regulation (required) of ROCK associated with nmda receptor
7) Confidence 0.11 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.25
In Abl and Abl-related gene (Arg) double-knock out mice, the extent of dendritic branching in substantially reduced [20] and treatment of developing cultured neurons with the Abl inhibitor, STI571, decreases the complexity of neuronal dendritic branching via an increase in RhoA activity [21] and possible activation of Rho-associated kinase (ROCK) [22-24].
Spec (possible) Positive_regulation (activation) of ROCK in neurons associated with targeted disruption
8) Confidence 0.11 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.15 Pain Relevance 0.14

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