INT263732

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2a, Neto1) transport (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
hippocampus 1
Grin2a (Mus musculus)
Neto1 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 78 97.32 Very High Very High Very High
Hippocampus 36 95.40 Very High Very High Very High
addiction 3 28.76 Quite Low
nMDA receptor 27 5.00 Very Low Very Low Very Low
Pyramidal cell 12 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
Neurotransmitter 9 5.00 Very Low Very Low Very Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 24 5.00 Very Low Very Low Very Low
Congenital Anomalies 18 5.00 Very Low Very Low Very Low
Convulsion 6 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Helminth Infection 3 5.00 Very Low Very Low Very Low
Influenza Virus Infection 3 5.00 Very Low Very Low Very Low
Contagious Ecthyma 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although Neto1 binds to both NR2A and NR2B, the loss of Neto1 leads to a reduction in the abundance of NR2A, but not NR2B, in the PSD fraction from hippocampus and a reduction in NR2A puncta in the CA1 region.
NR2A Binding (binds) of Neto1 in hippocampus associated with hippocampus
1) Confidence 0.41 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.12
We have shown that Neto1 interacts with NMDARs through the extracellular domain of their NR2 subunits, as well as intracellularly through PSD-95.
NR2 Binding (interacts) of Neto1
2) Confidence 0.35 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.15
Despite the ability of Neto1 to bind to both NR2A and NR2B subunits in vitro, the differential effect of Neto1 on NR2A- versus NR2B-containing NMDARs in vivo, might be mediated by the extracellular, membrane or cytoplasmic domains of these NR2 subunits.
NR2A Spec (might) Binding (bind) of Neto1
3) Confidence 0.30 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0

General Comments

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