INT264009

Context Info Confidence 0.47 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.49 Pain Relevance 1.27

mRNA processing (Syncrip) RNA binding (Syncrip) nucleus (Syncrip) cytoplasm (Syncrip)

Anatomy Link Frequency neurons 1 muscles 1 wrist 1 Syncrip (Mus musculus)

Pain Link Frequency Relevance Heat Pain 256 100.00 Sciatica 14 93.08 Hippocampus 24 84.60 fibrosis 8 65.20 Glutamate 117 62.56 Neurotransmitter 6 50.00 Lasting pain 2 41.40 Tendonitis 4 22.88 chemokine 9 5.00 Central nervous system 7 5.00

Disease Link Frequency Relevance Heat Pain 250 100.00 Neuropathic Pain 16 95.52 Nerve Root Compression 14 93.08 Radial Neuropathy 2 92.12 Myalgia 10 87.84 Hypertrophy 2 84.08 Targeted Disruption 78 83.88 Cumulative Trauma Disorders 20 78.08 Neuromuscular Disease 6 76.96 Muscle Disease 8 74.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The up-regulation of Syncrip and other mRNA processing genes was indicative of increased trafficking and translation of mRNA's in the dendritic processes of Glud1 hippocampal neurons.

Regulation (regulation) of Syncrip in neurons

1) Confidence 0.47 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.29 Pain Relevance 0.07

To our knowledge, no evaluation methods, including electromyographic (EMG) analysis techniques, have been used to characterize muscles affected with NSAP.

Regulation (affected) of NSAP in muscles associated with pain

2) Confidence 0.39 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2654455 Disease Relevance 1.16 Pain Relevance 0.60

In the current study, we have defined NSAP as a condition affecting the wrist extensor muscles.

Regulation (affecting) of NSAP in wrist associated with pain

3) Confidence 0.27 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2654455 Disease Relevance 1.04 Pain Relevance 0.60

General Comments

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