INT264101

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (CYP2D6, Bche) extracellular space (Bche) mitochondrion (CYP2D6)
extracellular region (Bche) small molecule metabolic process (CYP2D6) oxidoreductase activity (CYP2D6)
CYP2D6 (Homo sapiens)
Bche (Mus musculus)
Pain Link Frequency Relevance Heat
Antiemetics 1 93.04 High High
Analgesic 2 92.36 High High
antidepressant 5 90.64 High High
Central nervous system 7 5.00 Very Low Very Low Very Low
Glutamate 7 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Catechol-O-methyltransferase 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vomiting 1 93.04 High High
Disease 167 89.64 High High
Adverse Drug Reaction 13 16.32 Low Low
Cognitive Disorder 55 5.00 Very Low Very Low Very Low
Dementia 34 5.00 Very Low Very Low Very Low
Vascular Dementia 16 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 14 5.00 Very Low Very Low Very Low
Psychosis 8 5.00 Very Low Very Low Very Low
Frailty 8 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although most studies predict the safety of donepezil and galantamine, as the two principal cholinesterase inhibitors metabolized by CYP2D6-related enzymes, no pharmacogenetic studies have been performed so far on an individual basis to personalize the treatment, and most studies reporting safety issues are the result of pooling together pharmacological and clinical information obtained with conventional procedures.
CYP2D6 Binding (metabolized) of cholinesterase
1) Confidence 0.07 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0.33 Pain Relevance 0.18

General Comments

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