INT264219

Context Info Confidence 0.14 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 0.09

cytosol (HDC) small molecule metabolic process (HDC) lyase activity (HDC) cellular nitrogen compound metabolic process (HDC) cellular amino acid metabolic process (HDC)

HDC (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 5 68.28 agonist 7 55.52 antagonist 6 54.48 excitatory amino acid 1 39.08 depression 3 5.00 headache 3 5.00 Inflammation 2 5.00 nud 2 5.00 corticosteroid 1 5.00 sSRI 1 5.00

Disease Link Frequency Relevance Heat Vertigo 44 66.36 Disease 43 5.00 Vomiting 13 5.00 Tinnitus 7 5.00 Dizziness 6 5.00 Depression 5 5.00 Endolymphatic Hydrops 5 5.00 Deafness 4 5.00 Headache 3 5.00 Rupture 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further studies using an in situ hybridization method for quantifying the messenger RNA for histidine decarboxylase (HDC), the enzyme synthesizing HA, pointed to an up-regulation of HDC mRNA in the TM nuclei of cats treated with HA-like drugs (Tighilet et al 2002) (Figure 2).

Regulation (regulation) of HDC mRNA

1) Confidence 0.14 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2655085 Disease Relevance 0.07 Pain Relevance 0.09

General Comments

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