INT264378

Context Info Confidence 0.28 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

peptidase activity (MMP1, MMP13) extracellular region (MMP1, MMP13) proteinaceous extracellular matrix (MMP1, MMP13) extracellular space (MMP13) Golgi apparatus (MMP13) lysosome (MMP13)

MMP1 (Homo sapiens) MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 14 50.00 agonist 1 50.00 Inflammation 9 5.00 cytokine 6 5.00 rheumatoid arthritis 5 5.00 Osteoarthritis 5 5.00 Arthritis 3 5.00 Pain 1 5.00 Inflammatory stimuli 1 5.00 Immobilon 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 10 5.00 Syndrome 6 5.00 Chondrosarcoma 6 5.00 Arthritis 5 5.00 Osteoarthritis 5 5.00 Rheumatoid Arthritis 5 5.00 Repression 3 5.00 Diabetes Mellitus 2 5.00 Cancer 2 5.00 Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Endogenous MMP-1 and MMP-13 mRNA expression was unaffected by the overexpression of HA-PPAR?

MMP-1 Neg (unaffected) Regulation (unaffected) of Transcription (expression) of MMP-13

1) Confidence 0.28 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.