INT264422

Context Info Confidence 0.40 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.07

peptidase activity (MMP13) extracellular space (MMP13) extracellular region (MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) lysosome (MMP13)

MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 14 67.04 agonist 1 50.00 Inflammatory stimuli 1 41.80 cytokine 6 6.44 Inflammation 9 6.08 rheumatoid arthritis 5 5.00 Osteoarthritis 5 5.00 Arthritis 3 5.00 Pain 1 5.00 Immobilon 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 10 41.48 Syndrome 6 5.00 Chondrosarcoma 6 5.00 Arthritis 5 5.00 Osteoarthritis 5 5.00 Rheumatoid Arthritis 5 5.00 Repression 3 5.00 Diabetes Mellitus 2 5.00 Cancer 2 5.00 Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Combined treatment with rosiglitazone and LG268 further reduces MMP-1 and MMP-13 mRNA and hnRNA

Negative_regulation (reduces) of MMP-13 Binding (mRNA) of

1) Confidence 0.40 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0.07

General Comments

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