INT264442

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.42
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DR1) intracellular (DR1) DNA binding (DR1)
transcription factor binding (DR1)
Anatomy Link Frequency
proximal 1
DR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 12 91.60 High High
Inflammation 36 85.76 High High
cytokine 24 81.28 Quite High
metalloproteinase 56 50.00 Quite Low
agonist 4 50.00 Quite Low
rheumatoid arthritis 20 5.00 Very Low Very Low Very Low
Osteoarthritis 20 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 20 91.60 High High
Arthropathy 8 90.40 High High
INFLAMMATION 41 85.76 High High
Chondrosarcoma 24 31.28 Quite Low
Disease 8 24.00 Low Low
Syndrome 24 10.52 Low Low
Osteoarthritis 20 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 20 5.00 Very Low Very Low Very Low
Repression 12 5.00 Very Low Very Low Very Low
Diabetes Mellitus 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This allows ligand-dependent activation for RXR-RAR heterodimer on DR5, but not on DR1.
Positive_regulation (activation) of DR1
1) Confidence 0.16 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
The competitive binding model implicates competition for binding to the degenerate DR-1 site between RXR:PPAR?
Positive_regulation (degenerate) of DR-1 site
2) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.09 Pain Relevance 0.04
Although Figure 5 suggests that the putative DR-1 element of the DR-1/AP-1 site does not function as a traditional response element for RXR:PPAR?
Positive_regulation (putative) of DR-1 element
3) Confidence 0.09 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
heterodimer to a degenerate DR-1 site in the proximal (approximately -72 base pairs) region of the rabbit MMP-1 promoter.
Positive_regulation (degenerate) of DR-1 site in proximal
4) Confidence 0.09 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.34 Pain Relevance 0.16
These findings support the conclusions that (a) LG268 and rosiglitazone are each able to activate a consensus PPRE/DR-1 element in the SW-1353 cells and (b) combination treatment leads to synergistic activation of this element, presumably because both partners of the RXR:PPAR?
Positive_regulation (activate) of DR-1 element
5) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0

General Comments

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