INT264517

Context Info Confidence 0.17 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.50 Pain Relevance 0.22

nucleus (PTGDS, TFDP1) nucleoplasm (TFDP1) isomerase activity (PTGDS) transport (PTGDS) Golgi apparatus (PTGDS) DNA binding (TFDP1)

Anatomy Link Frequency chondrocytes 1 PTGDS (Homo sapiens) TFDP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 47 94.16 Inflammation 22 86.48 metalloproteinase 4 52.68 cytokine 5 5.00 COX-2 inhibitor 1 5.00 Central nervous system 1 5.00 cINOD 1 5.00 Inflammatory response 1 5.00 Pain 1 5.00 Multiple sclerosis 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 48 94.16 INFLAMMATION 24 86.48 Necrosis 1 50.44 Cancer 1 50.08 Apoptosis 3 25.24 Hypersensitivity 1 19.20 Targeted Disruption 4 16.72 Crystal Associated Disease 2 14.48 Disease 8 5.00 Atherosclerosis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, we have recently demonstrated that human chondrocytes express functional DP1 and CRTH-2 and that PGD2 downregulates MMP-1 and MMP-13 expressions through activation of the DP1 pathway [9].

PGD2 Positive_regulation (activation) of DP1 in chondrocytes

1) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 0.50 Pain Relevance 0.22

General Comments

This test has worked.