INT264521

Context Info Confidence 0.06 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.42 Pain Relevance 0.34

extracellular region (PTGDS, MMP1) isomerase activity (PTGDS) transport (PTGDS) Golgi apparatus (PTGDS) cytoplasm (PTGDS) peptidase activity (MMP1)

Anatomy Link Frequency chondrocytes 2 PTGDS (Homo sapiens) MMP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 22 99.80 Osteoarthritis 47 55.92 metalloproteinase 4 48.88 cytokine 5 18.96 Multiple sclerosis 1 6.40 COX-2 inhibitor 1 5.00 Central nervous system 1 5.00 cINOD 1 5.00 Inflammatory response 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 3 100.00 INFLAMMATION 24 99.80 Hypersensitivity 1 97.88 Targeted Disruption 4 95.40 Crystal Associated Disease 2 93.16 Atherosclerosis 3 78.04 Injury 1 60.44 Osteoarthritis 48 55.92 Cancer 1 54.24 Necrosis 1 53.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition to its anti-inflammatory effects, PGD2 was shown to induce the expression of collagen type II and aggrecan [7], to prevent apoptosis [8], and to inhibit the induction of MMP-1 and MMP-13 [52] in chondrocytes.

PGD2 Negative_regulation (inhibit) of Positive_regulation (induction) of MMP-1 in chondrocytes associated with inflammation and apoptosis

1) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 1.42 Pain Relevance 0.34

General Comments

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