INT264522

Context Info Confidence 0.03 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.22 Pain Relevance 0.40

Golgi apparatus (GPER, PTGDS) isomerase activity (PTGDS) transport (PTGDS) endoplasmic reticulum (GPER) cytoplasm (PTGDS) signal transducer activity (GPER)

Anatomy Link Frequency Th2 cells 1 GPER (Homo sapiens) PTGDS (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 22 98.56 Inflammatory response 1 88.24 Central nervous system 1 56.88 Osteoarthritis 47 46.24 cytokine 5 33.40 metalloproteinase 4 12.56 COX-2 inhibitor 1 5.00 cINOD 1 5.00 Pain 1 5.00 Multiple sclerosis 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 24 98.56 Volume Depletion And Dehydration 1 94.28 Crystal Associated Disease 2 90.16 Targeted Disruption 4 82.88 Apoptosis 3 54.96 Osteoarthritis 48 50.00 Disease 8 48.08 Atherosclerosis 3 5.00 Hypertension 1 5.00 Demyelinating Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PGD2 exerts its effects principally by binding and activating two plasma membrane receptors, the D prostanoid receptor (DP) 1 [15] and chemoattractant-receptor-like molecule expressed on Th2 cells (CRTH2), also known as DP2 [16].

chemoattractant-receptor-like molecule Binding (binding) of PGD2 in Th2 cells

1) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 1.22 Pain Relevance 0.40

General Comments

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