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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 12.58
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGFALS) extracellular space (IGFALS) extracellular region (IGFALS)
cell adhesion (IGFALS) nucleolus (IGFALS) nucleus (IGFALS)
Anatomy Link Frequency
spinal 1
muscles 1
motor neuron 1
IGFALS (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurobehavioral 13 87.76 High High
Spinal cord 53 87.00 High High
Inflammation 24 75.36 Quite High
imagery 82 71.04 Quite High
medulla 28 60.64 Quite High
Transcranial magnetic stimulation 20 46.60 Quite Low
Central nervous system 19 41.88 Quite Low
addiction 13 35.36 Quite Low
depression 28 32.00 Quite Low
Hippocampus 5 31.68 Quite Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 1237 100.00 Very High Very High Very High
Charcot Marie Tooth Disease 28 100.00 Very High Very High Very High
Progressive Bulbar Palsy 20 100.00 Very High Very High Very High
Disease 370 99.40 Very High Very High Very High
Atrophy 7 98.96 Very High Very High Very High
Lymphoproliferative Disease 8 98.64 Very High Very High Very High
Parkinson's Disease 37 98.12 Very High Very High Very High
Syndrome 107 97.76 Very High Very High Very High
Dementia 52 97.28 Very High Very High Very High
Nerve Degeneration 14 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More recent studies however have shown a decrease in incidence of both ALS and PDC in these areas over the past 40 years, although the incidence of PDC slightly increased during the eighties and nineties [37,40-42].


Negative_regulation (decrease) of ALS associated with motor neuron diseases
1) Confidence 0.33 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 1.08 Pain Relevance 0
A patient had been working as a spray painter at an industrial machine manufacturer for 20 yr (19) and was diagnosed with ALS.
Negative_regulation (diagnosed) of ALS associated with motor neuron diseases
2) Confidence 0.28 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC3023358 Disease Relevance 0.93 Pain Relevance 0.17
Despite the lack of a perfect single method for performing MUNE, it may have value in the assessment of progressive motor axon loss in ALS, and may have use as an end-point measure in clinical trials [199].


Negative_regulation (loss) of ALS associated with motor neuron diseases
3) Confidence 0.24 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 0.53 Pain Relevance 0.09
They are almost universal in ALS and its variants, where it can be seen in up to 95% of cases [2,3,161,162].
Negative_regulation (universal) of ALS associated with motor neuron diseases
4) Confidence 0.24 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 0.50 Pain Relevance 0.09
The terms 'bulbar onset ALS' and 'spinal onset ALS' have largely replaced the terms PBP and Charcot's ALS in current practice.
Negative_regulation (replaced) of ALS in spinal associated with charcot marie tooth disease, progressive bulbar palsy and motor neuron diseases
5) Confidence 0.24 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 3.32 Pain Relevance 0.06
When MND does occur in association with LPD, it appears to have both UMN and LMN involvement compatible with a diagnosis of ALS [8].
Negative_regulation (diagnosis) of ALS associated with lymphoproliferative disease and motor neuron diseases
6) Confidence 0.22 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2941760 Disease Relevance 2.02 Pain Relevance 0.04
This would implicate any absolute or relative cystatin C deficiency in ALS as both a potential contributor to disease pathogenesis and a potential therapeutic target.
Negative_regulation (deficiency) of ALS associated with disease and motor neuron diseases
7) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.89 Pain Relevance 0
The majority of cystatin C in the CSF is produced by the choroid plexus [25], but it is unclear whether the apparent reductions in CSF levels in ALS patients are an independent etiological factor contributing to motor neuron degeneration, a downstream result of disease pathogenesis, or a compensatory response to ALS pathology.
Spec (whether) Negative_regulation (reductions) of ALS in motor neuron associated with disease, nerve degeneration and motor neuron diseases
8) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.78 Pain Relevance 0
Next, we repeated these statistical analyses using data from specific patient subgroups, in order to determine if either measure of CSF cystatin C can be used to differentiate ALS patients from disease controls in specific patient subpopulations.
Negative_regulation (differentiate) of ALS associated with disease and motor neuron diseases
9) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 1.42 Pain Relevance 0
This study of Jimi and colleagues showed that changes in the levels of AQP4 mRNA in muscles with ALS and other neurogenic atrophies were essentially the same, although there was a greater decrease of AQP4 in ALS than in other neurogenic atrophies.
Negative_regulation (decrease) of ALS in muscles associated with atrophy and motor neuron diseases
10) Confidence 0.07 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.81 Pain Relevance 0
At about the same time, in Switzerland, Walter Morgenthaler published Ein Geisteskranker als Künstler (A Psychiatric Patient as Artist), describing the drawings of one of his patients, Adolf Wölfli.
Negative_regulation (published) of als
11) Confidence 0.06 Published 2008 Journal GMS Psycho-Social Medicine Section Body Doc Link PMC2736519 Disease Relevance 0.29 Pain Relevance 0

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