INT264714

Context Info Confidence 0.46 First Reported 2009 Last Reported 2011 Negated 1 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.67 Pain Relevance 0.04

extracellular space (Prom1) plasma membrane (Prom1) cilium (Prom1)

Prom1 (Mus musculus)

Pain Link Frequency Relevance Heat imagery 55 70.00 alcohol 1 25.76 ischemia 7 5.00 Central nervous system 6 5.00 isoflurane 6 5.00 positron emission tomography 5 5.00 anesthesia 3 5.00 Thoracotomy 3 5.00 fibrosis 2 5.00 palliative 1 5.00

Disease Link Frequency Relevance Heat Cancer 227 100.00 Brain Tumor 64 92.24 Glioma 49 89.56 Apoptosis 32 58.28 Leukemia 2 50.28 Solid Tumor 2 41.96 Body Weight 4 22.16 Glioblastoma 30 5.00 Targeted Disruption 14 5.00 Death 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We also found that a small population of CD133-negative cells in the tumors bound injected AC133.1-Alexa488.

Positive_regulation (population) of Neg (negative) Gene_expression (injected) of AC133 associated with cancer

1) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004948 Disease Relevance 0.24 Pain Relevance 0

Cells expressing higher levels of CD133 than the immunoglobulin G (IgG) controls were considered positive.

Positive_regulation (levels) of Gene_expression (expressing) of CD133

2) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.06 Pain Relevance 0.04

The clinical value of CD133-expression in tumors remains unclear, but some groups have reported that the increased expression of CD133 is associated with a poor prognosis [67, 68].

Positive_regulation (increased) of Gene_expression (expression) of CD133 associated with cancer

3) Confidence 0.23 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.37 Pain Relevance 0

We also observed Flk-1 and CD133 were expressed at high level on undifferentiated hESCs (Figure S1), consistent with previous reports [10], [12]. hESC-ECs morphologically resembled HUVECs, which were uniformly flat, adherent, and cobblestone-like in appearance.

Positive_regulation (level) of Gene_expression (expressed) of CD133

4) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0

General Comments

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