INT264778

Context Info Confidence 0.02 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.21

cytoplasm (CA2, Gabbr1) lyase activity (CA2) signal transducer activity (Gabbr1) response to stress (CA2) cytosol (CA2) extracellular space (CA2)

CA2 (Homo sapiens) Gabbr1 (Mus musculus)

Pain Link Frequency Relevance Heat gABA 20 100.00 Potency 10 81.56 agonist 45 27.04 antagonist 10 7.92 cocaine 7 5.00 addiction 7 5.00 alcohol 6 5.00 Neurotransmitter 4 5.00 tolerance 4 5.00 GABAergic 4 5.00

Disease Link Frequency Relevance Heat Anxiety Disorder 13 5.00 Drug Dependence 5 5.00 Cognitive Disorder 3 5.00 Demyelinating Disease 2 5.00 Sleep Disorders 2 5.00 Spasticity 2 5.00 Absence Epilepsy 1 5.00 Depression 1 5.00 Stress 1 5.00 INFLAMMATION 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Of interest, this effect of Ca2+ was not observed with baclofen, suggesting that the chlorophenyl group of baclofen prevents the action of Ca2+ ions, pointing to the possibility that Ca2+ directly binds within the GABA binding site in the GABAB1 VFT.

Ca2 Binding (binds) of GABAB1 associated with gaba

1) Confidence 0.02 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656813 Disease Relevance 0 Pain Relevance 0.21

General Comments

This test has worked.