INT264973

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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.20
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MYD88) signal transduction (MYD88) plasma membrane (MYD88)
intracellular (MYD88) cytoplasm (MYD88)
MYD88 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 89 86.84 High High
Opioid 67 82.56 Quite High
cytokine 29 80.76 Quite High
Inflammatory response 6 79.84 Quite High
analgesia 20 71.76 Quite High
IPN 19 61.84 Quite High
agonist 15 61.84 Quite High
Pain 30 53.92 Quite High
Endogenous opioid 2 45.60 Quite Low
chemokine 7 38.80 Quite Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 67 98.96 Very High Very High Very High
Sepsis 67 98.32 Very High Very High Very High
Obesity 22 94.88 High High
INFLAMMATION 89 86.84 High High
Insulin Resistance 20 80.56 Quite High
Inflammatory Pain 19 61.84 Quite High
Pain 29 53.92 Quite High
Nociception 24 50.00 Quite Low
Viral Infection 1 47.28 Quite Low
Infection 89 43.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fig. 3 shows that sepsis induced TLR4 protein levels and activation, as demonstrated by an increase in TLR4/MyD88 interaction in the three tissues investigated, and atorvastatin reduced this early step of TLR4 activation and also TLR4 expression (Fig. 3A–C).
MyD88 Binding (interaction) of associated with sepsis
1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.92 Pain Relevance 0.20
In contrast, TLR activation induces coupling to an adapter protein, MyD88, and stimulation of several intrinsic kinases including interleukin-1 receptor accessory protein kinase leading to NF-?
MyD88 Binding (coupling) of
2) Confidence 0.12 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.18 Pain Relevance 0.52
Once TLR7 recognizes ssRNA, the adaptor protein myeloid differentiation primary response protein 88 (MyD88), via down-stream signal activation of transcription factors, results in the production of type I Interferons (IFNs) and inhibition of viral replication.
MyD88 Binding (recognizes) of
3) Confidence 0.07 Published 2009 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2794489 Disease Relevance 0.10 Pain Relevance 0.03
Upon recognition of the presence of microbes through sensing pathogen-associated molecular patterns, TLRs can bind any of the 4 known activating adaptors: (i) Myeloid differentiating factor-88 (MyD88), (ii) MyD88 adapter-like (Mal), (iii) TIR domain-containing adapter-inducing IFN-?
MyD88 Binding (bind) of
4) Confidence 0.05 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0 Pain Relevance 0
Upon recognition of the presence of microbes through sensing pathogen-associated molecular patterns, TLRs can bind any of the 4 known activating adaptors: (i) Myeloid differentiating factor-88 (MyD88), (ii) MyD88 adapter-like (Mal), (iii) TIR domain-containing adapter-inducing IFN-?
MyD88 Binding (bind) of
5) Confidence 0.05 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0 Pain Relevance 0

General Comments

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