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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2C19, CYP3A4) oxidoreductase activity (CYP2C19, CYP3A4) endoplasmic reticulum (CYP2C19, CYP3A4)
enzyme binding (CYP2C19, CYP3A4) lipid metabolic process (CYP3A4) cytoplasm (CYP3A4)
CYP2C19 (Homo sapiens)
CYP3A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
methadone 27 99.96 Very High Very High Very High
action potential duration 1 72.08 Quite High
Action potential 2 68.64 Quite High
drug abuse 5 50.00 Quite Low
cocaine 8 49.12 Quite Low
potassium channel 2 40.00 Quite Low
addiction 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arrhythmia Under Development 32 93.72 High High
Cv Unclassified Under Development 2 91.12 High High
Hypokalemia 1 85.12 High High
Heart Rate Under Development 14 75.72 Quite High
Syndrome 8 56.00 Quite High
Congenital Anomalies 4 50.72 Quite High
Drug Dependence 4 50.00 Quite Low
Coronary Heart Disease 1 36.52 Quite Low
Infection 7 32.96 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 14 32.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It specifically inhibits the CYP2C19, CYP2C9, and CYP3A4 enzymes that metabolize methadone.
CYP2C19 Binding (metabolize) of CYP3A4 associated with methadone
1) Confidence 0.18 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657284 Disease Relevance 0.72 Pain Relevance 1.09

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