INT265

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Context Info
Confidence 0.59
First Reported 1977
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.34
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Por) oxidoreductase activity (Por) endoplasmic reticulum (Por)
enzyme binding (Por)
Por (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 1 92.00 High High
Codeine 2 91.68 High High
antagonist 2 82.64 Quite High
opioid receptor 1 82.20 Quite High
Endogenous opioid 1 78.16 Quite High
Opioid 1 75.00 Quite High
Paracetamol 2 50.00 Quite Low
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 2 75.00 Quite High
Drug-induced Liver Injury 2 66.08 Quite High
Necrosis 2 62.72 Quite High
Cancer 2 62.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest that NADPH-cytochrome P-450 reductase, which is decreased 40% by cyclophosphamide pretreatment, is not rate-limiting in elimination of adriamycin.
Negative_regulation (decreased) of NADPH-cytochrome P-450 reductase
1) Confidence 0.59 Published 1982 Journal Cancer Chemother. Pharmacol. Section Abstract Doc Link 6819097 Disease Relevance 0 Pain Relevance 0.05
Present data confirmed previous results that acute IMO reduced testicular P450c17 activity and implicate that decreased activity of NADPH-P450 reductase could be responsible for the inhibition of P450c17 under IMO conditions, while NADH-b5 reductase is probably not involved.
Negative_regulation (decreased) of NADPH-P450 reductase
2) Confidence 0.53 Published 1998 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 9712411 Disease Relevance 0.15 Pain Relevance 0.27
The binding of cyanide to cytochrome P-450 resulted in innhibition of NADPH-cytochrome P-450 reductase activity.
Negative_regulation (innhibition) of NADPH-cytochrome P-450
3) Confidence 0.38 Published 1977 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 22768 Disease Relevance 0 Pain Relevance 0.09
RESULTS: Rats intoxicated with acetaminophen showed considerable impairment in the activities of drug metabolizing microsomal enzymes, such as cytochrome P450, NADPH Cyt P450 reductase and b(5) when compared with the control rats.
Negative_regulation (impairment) of NADPH Cyt P450 reductase
4) Confidence 0.28 Published 2006 Journal World J. Gastroenterol. Section Body Doc Link 16804966 Disease Relevance 0.19 Pain Relevance 0

General Comments

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