INT265256

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.17
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gria2, Cdh2) protein complex (Gria2, Cdh2) cell adhesion (Cdh2)
endoplasmic reticulum (Gria2)
Anatomy Link Frequency
spines 1
Gria2 (Rattus norvegicus)
Cdh2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
conotoxin 1 89.04 High High
imagery 7 52.24 Quite High
Glutamate 33 38.24 Quite Low
Glutamate receptor 20 6.48 Low Low
depression 11 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
potassium channel 3 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 2 100.00 Very High Very High Very High
Stress 6 68.32 Quite High
Depression 11 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Intellectual Impairment 3 5.00 Very Low Very Low Very Low
Togavirus Infection 2 5.00 Very Low Very Low Very Low
Rupture 2 5.00 Very Low Very Low Very Low
Brain Hemorrhage 1 5.00 Very Low Very Low Very Low
Limbic Encephalitis 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, the latter two proteins co-purify with native AMPA-Rs without using chemical crosslinkers in stark contrast to the interaction between the GluA2 NTD and N-cadherin.
GluA2 Binding (interaction) of N-cadherin
1) Confidence 0.02 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.04
Furthermore, the extracellular N-terminal domain of GluR2 can interact directly with the cell adhesion molecule N-cadherin to promote the formation and growth of dendritic spines [31], [32].
GluR2 Binding (interact) of N-cadherin in spines associated with adhesions
2) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0.17 Pain Relevance 0.03

General Comments

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