INT265265

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.16 Pain Relevance 0

cell differentiation (NAV1) cytoplasm (NAV1) transmembrane transport (SCN5A)

Anatomy Link Frequency oocytes 2 SCN5A (Homo sapiens) NAV1 (Homo sapiens) SCN5A - R878C (1)

Pain Link Frequency Relevance Heat Mexiletine 7 5.00 lidocaine 5 5.00 addiction 1 5.00 tetrodotoxin 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Heart Arrhythmia 10 84.32 Heart Rate Under Development 21 5.00 Disease 4 5.00 Sudden Infant Death Syndrome 2 5.00 Syncope 1 5.00 Premature Beats 1 5.00 Syndrome 1 5.00 Arrhythmias 2 Under Development 1 5.00 Cv Unclassified Under Development 1 5.00 Cv General 2 Under Development 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To test for the effect of the simultaneously produced R878C-hNav1.5 mutant on the expression of WT-hNav1.5 in Xenopus oocytes, we co-injected equal amounts of the respective cRNAs into oocytes and determined the peak current amplitudes and kinetic parameters of the whole-cell Na+ currents.

R878C-hNav1.5 (R878C) Regulation (effect) of Gene_expression (expression) of hNav1 in oocytes

1) Confidence 0.01 Published 2008 Journal Acta Physiologica (Oxford, England) Section Body Doc Link PMC2659387 Disease Relevance 0.16 Pain Relevance 0

General Comments

This test has worked.