INT265317

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.90
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Smad3) intracellular (Smad3) DNA binding (Smad3)
protein complex (Smad3) cytoplasm (Smad3) nucleus (Smad3)
Anatomy Link Frequency
chondrocytes 2
articular 2
Smad3 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 182 61.60 Quite High
Kinase C 1 25.64 Quite Low
cytokine 10 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 10 97.64 Very High Very High Very High
Targeted Disruption 2 95.32 Very High Very High Very High
Retinal Diseases 2 85.88 High High
Ganglion Cysts 13 68.24 Quite High
Osteoarthritis 192 61.60 Quite High
Disease 24 54.12 Quite High
Apoptosis 31 48.72 Quite Low
Aging 26 42.44 Quite Low
Cytomegalovirus Infection 2 25.44 Quite Low
Fibrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In articular chondrocytes treated with azacytidine, reduced Smad2 and Smad3 expression and signaling and increased Smad1/5 expression correlated with elevated synthesis of type X collagen and alkaline phosphatase.
Negative_regulation (reduced) of Gene_expression (expression) of Smad3 in articular
1) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.44 Pain Relevance 0.03
Overexpression of both Smad2 and Smad3 blocked spontaneous maturation in Smad3-deficient chondrocytes [70,71].
Negative_regulation (blocked) of Gene_expression (Overexpression) of Smad3 in chondrocytes
2) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.19 Pain Relevance 0.03
Genes monitored were smad2, smad3, TGF-?
Negative_regulation (monitored) of Gene_expression (Genes) of smad3
3) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.27 Pain Relevance 0

General Comments

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