INT265455

Context Info Confidence 0.04 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.27 Pain Relevance 0

cell differentiation (CSPG4) mitochondrion (CASP8) intracellular (CSPG4) cytoplasm (CASP8) signal transducer activity (CSPG4) cytosol (CASP8)

CSPG4 (Homo sapiens) CASP8 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 10 50.00 cytokine 9 26.00 Pain 1 5.00 headache 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 24 87.12 Stress 12 66.64 INFLAMMATION 10 50.00 Death 12 30.28 Disorders Of The Lacrimal System 3 5.00 Necrosis 2 5.00 Cancer 2 5.00 Dry Eye 2 5.00 Pain 1 5.00 Toxicity 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

HMW-HA completely prevented caspase-3 and caspase-8 activation at the dose of 25 mJ/cm2 of UVB.

HMW-HA Negative_regulation (prevented) of Positive_regulation (activation) of caspase-8

1) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.27 Pain Relevance 0

General Comments

This test has worked.