INT265475

Context Info Confidence 0.03 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.93 Pain Relevance 0.12

IGKV1D-22 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 9 63.52 Inflammation 10 63.12 headache 1 43.56 Pain 1 42.12 antagonist 1 5.00

Disease Link Frequency Relevance Heat Death 12 98.16 Apoptosis 24 97.08 INFLAMMATION 10 63.12 Disorders Of The Lacrimal System 3 52.00 Dry Eye 2 47.52 Blindness 1 47.32 Headache 1 43.56 Pain 1 42.12 Radiation Sickness 1 28.40 Stress 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Activation of these initiator caspases (caspase-8 and -9) via either pathway activates caspase-3 that cleaves a variety of cellular death subtrates leading to apoptosis [7].

Positive_regulation (activates) of Positive_regulation (Activation) of and -9 associated with apoptosis and death

1) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.93 Pain Relevance 0.12

General Comments

This test has worked.