INT26551

Context Info Confidence 0.67 First Reported 1984 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 19 Total Number 20 Disease Relevance 11.05 Pain Relevance 7.98

extracellular space (KNG1) extracellular region (KNG1) plasma membrane (KNG1)

Anatomy Link Frequency smooth muscle 4 endothelial cells 4 skin 4 neuronal 2 joints 2 KNG1 (Homo sapiens)

Pain Link Frequency Relevance Heat bradykinin 115 100.00 b2 receptor 18 100.00 adenocard 2 99.80 Inflammation 89 99.78 Inflammatory mediators 7 99.28 dexamethasone 5 98.10 cytokine 18 93.12 Pain 43 92.72 Morphine 83 91.12 Calcitonin gene-related peptide 34 89.92

Disease Link Frequency Relevance Heat Targeted Disruption 25 99.88 Pressure And Volume Under Development 44 99.80 INFLAMMATION 105 99.78 Hereditary Angioedema 88 99.60 Pressure Volume 2 Under Development 4 99.60 Injury 14 99.00 Increased Venous Pressure Under Development 88 98.12 Nociception 13 97.68 Shock 3 96.16 Stress 16 95.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CONCLUSIONS: Our data indicate that in patients with unstable angina pectoris, intracoronary thrombus formation is associated with a hypercoagulative state, including activation of the contact phase and of the kallikrein system and increased bradykinin generation.

Positive_regulation (increased) of Gene_expression (generation) of bradykinin

1) Confidence 0.67 Published 1995 Journal Circulation Section Body Doc Link 7743613 Disease Relevance 0 Pain Relevance 0

AN69-associated reactions are a second group, and are probably mediated by membrane-induced bradykinin generation coupled with ACE-inhibitor induced prolongation of bradykinin half-life.

Positive_regulation (induced) of Gene_expression (generation) of bradykinin associated with bradykinin

2) Confidence 0.45 Published 1994 Journal Nephrol. Dial. Transplant. Section Abstract Doc Link 8065604 Disease Relevance 0 Pain Relevance 0.10

Topical application of D3 or light chain enhanced bradykinin generation and edema formation in the mouse skin.

Positive_regulation (enhanced) of Gene_expression (generation) of bradykinin in skin associated with pressure and volume under development and bradykinin

3) Confidence 0.42 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16116231 Disease Relevance 0.27 Pain Relevance 0.53

Thus, expression of a mutant ras protein in Rat 13 cells increases their expression of the bradykinin receptor and their sensitivity to ligand stimulation of mitogenesis.

Positive_regulation (increases) of Gene_expression (expression) of bradykinin associated with bradykinin

4) Confidence 0.42 Published 1989 Journal J. Cell. Sci. Section Abstract Doc Link 2561128 Disease Relevance 0.07 Pain Relevance 0.35

However, the low dose of dexamethasone blunted the vasodilatory response to bradykinin, whereas the high dose (5 mg/kg) was found to enhance the dilatory properties of bradykinin at concentrations of 4 x 10(-3) M.

Positive_regulation (enhance) of Gene_expression (properties) of bradykinin associated with bradykinin and dexamethasone

5) Confidence 0.40 Published 1989 Journal Acta Neuropathol. Section Abstract Doc Link 2750477 Disease Relevance 0 Pain Relevance 0.60

Proteolytic bradykinin production on endothelial cells is restored following degradation of cell surface GAG through heparinase.

Positive_regulation (following) of Gene_expression (production) of bradykinin in endothelial cells associated with bradykinin

6) Confidence 0.37 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16116231 Disease Relevance 0.29 Pain Relevance 0.52

Proteolytic bradykinin production on endothelial cells is restored following degradation of cell surface GAG through heparinase.

Positive_regulation (restored) of Gene_expression (production) of bradykinin in endothelial cells associated with bradykinin

7) Confidence 0.37 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16116231 Disease Relevance 0.29 Pain Relevance 0.52

The data allow us to hypothesize that a transient increase in bradykinin receptor expression might be caused by cell injury due to disruption of the axon.

Positive_regulation (increase) of Gene_expression (expression) of bradykinin associated with injury and bradykinin

8) Confidence 0.36 Published 1996 Journal Neuroscience Section Abstract Doc Link 8938754 Disease Relevance 0.17 Pain Relevance 0.57

Excess bradykinin production leads to acute HAE attacks as a result of increased vasodilatation, vascular permeability, and contraction of nonvascular smooth muscle[3].

Positive_regulation (Excess) of Gene_expression (production) of bradykinin in smooth muscle associated with hereditary angioedema, increased venous pressure under development and bradykinin

9) Confidence 0.34 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2965712 Disease Relevance 1.58 Pain Relevance 0.18

Excess bradykinin production leads to acute HAE attacks as a result of increased vasodilatation, vascular permeability, and contraction of nonvascular smooth muscle[3].

Positive_regulation (leads) of Gene_expression (production) of bradykinin in smooth muscle associated with hereditary angioedema, increased venous pressure under development and bradykinin

10) Confidence 0.24 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2965712 Disease Relevance 1.57 Pain Relevance 0.18

These studies show that overexpression of human bradykinin B2 receptor causes a sustained reduction of blood pressure in transgenic mice.

Positive_regulation (overexpression) of Gene_expression (overexpression) of bradykinin in blood associated with targeted disruption and b2 receptor

11) Confidence 0.17 Published 1997 Journal Hypertension Section Abstract Doc Link 9039147 Disease Relevance 0.90 Pain Relevance 0.36

Hypotension in transgenic mice overexpressing human bradykinin B2 receptor.

Positive_regulation (overexpressing) of Gene_expression (overexpressing) of bradykinin associated with targeted disruption, pressure volume 2 under development and b2 receptor

12) Confidence 0.12 Published 1997 Journal Hypertension Section Title Doc Link 9039147 Disease Relevance 1.00 Pain Relevance 0.38

2.6 increased levels of bradykinin and adenosine [115,116]

Positive_regulation (increased) of Gene_expression (levels) of bradykinin associated with adenocard and bradykinin

13) Confidence 0.05 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1820789 Disease Relevance 0.31 Pain Relevance 0.32

In the context of bradykinin mediated angioedema, they act on the kallikrein-kinin system by increasing synthesis of bradykinin.

Positive_regulation (increasing) of Gene_expression (synthesis) of bradykinin associated with pressure and volume under development and bradykinin

14) Confidence 0.05 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2918592 Disease Relevance 0.83 Pain Relevance 0.21

1.3.8 increased levels of bradykinin [116]

Positive_regulation (increased) of Gene_expression (levels) of bradykinin associated with bradykinin

15) Confidence 0.05 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1820789 Disease Relevance 0.53 Pain Relevance 0.35

Some studies have demonstrated an enhanced expression of large-molecular-weight HSPs in diseased systematic joints.

Positive_regulation (enhanced) of Gene_expression (expression) of large-molecular-weight in joints

16) Confidence 0.04 Published 2002 Journal J Craniofac Surg Section Abstract Doc Link 12218804 Disease Relevance 0.51 Pain Relevance 0.15

Kininogen consumption corresponds to increased BDK production.

Positive_regulation (increased) of Gene_expression (production) of BDK

17) Confidence 0.03 Published 1984 Journal Ann. Biol. Clin. (Paris) Section Abstract Doc Link 6233919 Disease Relevance 0.75 Pain Relevance 0.24

Of importance, not all ACE inhibitors increase bradykinin production to a similar extent.

Neg (not) Positive_regulation (increase) of Gene_expression (production) of bradykinin associated with bradykinin

18) Confidence 0.03 Published 2007 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2039813 Disease Relevance 0.45 Pain Relevance 0.49

In inflamed skin inflammatory mediators and their receptors are frequently overexpressed [34,35], among them particularly bradykinin and its receptors [36].

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of bradykinin in skin associated with inflammatory mediators and bradykinin

19) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2672059 Disease Relevance 0.54 Pain Relevance 0.96

contributes to the amplification of inflammatory processes promoting the production of secondary modulators such as NO, bradykinin and prostaglandins, which can in turn exert modulatory actions on neuronal activity [9,36].

Positive_regulation (promoting) of Gene_expression (production) of bradykinin in neuronal associated with inflammation and bradykinin

20) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731738 Disease Relevance 0.98 Pain Relevance 0.96

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