INT265659

Context Info Confidence 0.43 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.78 Pain Relevance 1.57

cytosol (COMT) mitochondrion (COMT) small molecule metabolic process (COMT) plasma membrane (COMT) cytoplasm (COMT)

COMT (Homo sapiens)

Pain Link Frequency Relevance Heat Catechol-O-methyltransferase 222 100.00 Pain 44 99.96 Face pain 4 98.64 Catecholamine 6 98.32 Central nervous system 10 92.60 IPN 12 78.88 Dopamine 2 40.80 noradrenaline 2 39.76 Lasting pain 2 7.52 Inflammation 16 5.00

Disease Link Frequency Relevance Heat Pain 44 99.96 Facial Pain 4 98.64 Manic Depressive Disorder 2 92.56 Schizophrenia 2 91.68 Cancer 6 90.40 Inflammatory Pain 12 78.88 Anaplastic Astrocytoma 16 73.84 INFLAMMATION 20 5.00 Neuropathic Pain 8 5.00 Nociception 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Myofacial pain patients exhibit lower COMT activity relative to controls [7], and COMT inhibition increases pain sensitivity in rodents by promoting catecholamine stimulation of ?

Positive_regulation (increases) of Negative_regulation (inhibition) of COMT associated with pain, catechol-o-methyltransferase, catecholamine and face pain

1) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.37 Pain Relevance 1.08

-dependent COMT downregulation was indeed mediated by the NF-?

Positive_regulation (mediated) of Negative_regulation (downregulation) of COMT associated with catechol-o-methyltransferase

2) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.41 Pain Relevance 0.48

General Comments

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