INT265970

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.20
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNNI2) nucleus (TNNI2)
Anatomy Link Frequency
muscle 1
TNNI2 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Contracture 20 99.68 Very High Very High Very High
Syndrome 59 53.76 Quite High
Recurrence 2 51.24 Quite High
Cleidocranial Dysplasia 1 44.48 Quite Low
Scoliosis 2 43.48 Quite Low
Cognitive Disorder 2 39.56 Quite Low
Congenital Anomalies 6 16.72 Low Low
Clubfoot 5 15.40 Low Low
Arthrogryposis 17 5.00 Very Low Very Low Very Low
Growth Problems 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism by which mutations in TNNI2 cause contractures is unclear but troponin I binds to actin and tropomyosin, and in the absence of Ca2+ prevents muscle contraction.
troponin I Binding (binds) of in muscle associated with contracture
1) Confidence 0.37 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2663550 Disease Relevance 0.20 Pain Relevance 0

General Comments

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