INT266105

Context Info Confidence 0.24 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.62 Pain Relevance 0.03

cytoplasm (SH2B2, HPS1) signal transducer activity (SH2B2) cytosol (SH2B2) pigmentation (HPS1) signal transduction (SH2B2) plasma membrane (SH2B2)

SH2B2 (Homo sapiens) HPS1 (Homo sapiens)

Pain Link Frequency Relevance Heat Catechol-O-methyltransferase 109 52.64 Pain 19 5.00 Catecholamine 7 5.00 Dopamine 3 5.00 Fibrositis 2 5.00 cytokine 1 5.00 Lasting pain 1 5.00 Inflammation 1 5.00 Morphine 1 5.00 addiction 1 5.00

Disease Link Frequency Relevance Heat Hantavirus Infection 78 100.00 Pain 19 5.00 Cognitive Disorder 7 5.00 Schizophrenia 5 5.00 Temporomandibular Joint Disorders 5 5.00 Anxiety Disorder 3 5.00 Hyperhomocysteinemia 2 5.00 Sleep Disorders 2 5.00 Cardiovascular Disease 2 5.00 Neurodegenerative Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Also consistent with previous studies [37], enzymatic activity corresponding to both the APS and HPS haplotypes was reduced compared to the LPS haplotype (F6,7?

APS Positive_regulation (corresponding) of Gene_expression (haplotypes) of HPS associated with hantavirus infection

1) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.62 Pain Relevance 0.03

General Comments

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