INT266396

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ager) nucleus (S100a4) plasma membrane (Ager)
cytoplasm (Ager)
Ager (Mus musculus)
S100a4 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 97.60 Very High Very High Very High
Osteoarthritis 2 96.60 Very High Very High Very High
Inflammation 55 44.56 Quite Low
Abeta 12 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 31 96.92 Very High Very High Very High
Osteoarthritis 2 96.60 Very High Very High Very High
Injury 6 76.72 Quite High
INFLAMMATION 58 44.56 Quite Low
Breast Cancer 2 42.00 Quite Low
Colon Cancer 1 33.32 Quite Low
Targeted Disruption 4 24.80 Low Low
Apoptosis 14 17.84 Low Low
Stress 13 5.00 Very Low Very Low Very Low
Diabetes Mellitus 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S100A4 binds to RAGE, and has been implicated in upregulation of MMP-13 (Matrix Metalloproteinase 13) in osteoarthritis, which leads to tissue remodeling [124].
RAGE Binding (binds) of S100A4 associated with metalloproteinase and osteoarthritis
1) Confidence 0.01 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.59 Pain Relevance 0.10

General Comments

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