INT266414

Context Info Confidence 0.03 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.91 Pain Relevance 0.20

cytoplasm (HMGB1, Mapk8) nucleus (HMGB1, Mapk8) nucleoplasm (HMGB1) mitochondrion (Mapk8) DNA binding (HMGB1) cytosol (Mapk8)

HMGB1 (Homo sapiens) Mapk8 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 55 99.92 cytokine 11 86.32 Abeta 12 5.00 fibrosis 4 5.00 Osteoarthritis 2 5.00 Inflammatory response 2 5.00 metalloproteinase 2 5.00 Arthritis 2 5.00 endometriosis 1 5.00 Inflammatory marker 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 58 99.92 Apoptosis 14 95.80 Adhesions 8 95.36 Cancer 31 86.08 Hepatocellular Cancer 1 70.48 Cirrhosis 1 68.24 Stress 13 5.00 Diabetes Mellitus 12 5.00 Lung Cancer 7 5.00 Disease 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

HMGB1 signaling, in part through RAGE, is associated with ERK1, ERK2, Jun-NH2-kinase (JNK), and p38 signaling.

HMGB1 Binding (associated) of JNK

1) Confidence 0.03 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.91 Pain Relevance 0.20

General Comments

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