INT26705

Context Info Confidence 0.67 First Reported 1989 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 3.99 Pain Relevance 2.74

cell proliferation (ADRA1D) plasma membrane (ADRA1D) cell-cell signaling (ADRA1D) DNA metabolic process (ADRA1D) signal transducer activity (ADRA1D)

Anatomy Link Frequency PSC 1 fat cell 1 dorsal horn 1 ADRA1D (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 3 99.64 Dorsal horn 3 99.40 Potency 2 97.88 Chronic pancreatitis 8 95.72 Spinal cord 1 95.56 intrathecal 5 93.12 Clonidine 1 92.80 allodynia 7 92.20 agonist 3 87.48 adenocard 1 87.48

Disease Link Frequency Relevance Heat Obesity 9 98.80 Herpes Simplex Virus Infection 5 98.64 Inflammatory Bowel Disease 10 98.38 Primary Sclerosing Cholangitis 5 97.28 Pancreatitis 9 95.72 Neuropathic Pain 7 92.20 Herpes Zoster 1 81.52 Post Operative Pain 3 79.52 Fibrosis 2 78.96 Disease 2 75.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The localization and density of the three messenger RNAs closely resembled those of other rare (alpha2, alpha5 and beta1) transcripts but their distribution also overlapped that of the predominant alpha1, beta2 and gamma2 subunit transcripts.

Transcription (transcripts) of alpha1

1) Confidence 0.67 Published 1998 Journal Neuroscience Section Abstract Doc Link 9740400 Disease Relevance 0 Pain Relevance 0.13

Glycine receptor alpha1-subunit mRNA was decreased in the lumbar dorsal horn at the herpetic, but not postherpetic stage, without alteration in alpha3-subunit mRNA.

Neg (without) Transcription (decreased) of alpha1 in dorsal horn associated with dorsal horn and herpes simplex virus infection

2) Confidence 0.67 Published 2010 Journal J. Pharmacol. Sci. Section Abstract Doc Link 20173309 Disease Relevance 1.25 Pain Relevance 1.26

Expression of mRNA for collagen alpha1(I), alpha-smooth muscle actin or CTGF were all increased and co-localized exclusively to activated PSC in ACP.

Transcription (Expression) of alpha1 in PSC associated with primary sclerosing cholangitis and chronic pancreatitis

3) Confidence 0.67 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 1.30 Pain Relevance 0.70

Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis revealed that the glycine receptor alpha1, alpha2, beta subunits and gephyrin mRNAs were expressed at comparable levels in strychnine-treated and untreated cultures.

Transcription (expressed) of alpha1

4) Confidence 0.52 Published 1998 Journal J. Cell. Sci. Section Abstract Doc Link 9427682 Disease Relevance 0 Pain Relevance 0.09

The levels of expression of Na+, K+-ATPase alpha1- and beta1-isoform proteins were also lower in UC patients than in controls, although there were no differences in Na+, K+-ATPase alpha1- and beta1-isoform mRNA levels between the two groups.

Transcription (levels) of alpha1 associated with inflammatory bowel disease

5) Confidence 0.52 Published 2004 Journal J. Pathol. Section Abstract Doc Link 15307141 Disease Relevance 0.78 Pain Relevance 0.07

For alpha-2 antagonists, the potency order was: yohimbine greater than idazoxan greater than SK&F-86,466 much greater than benextramine; 3) a description of the impact of benextramine (irreversible alpha-1/alpha-2 antagonist) on human fat cell alpha-2 adrenergic receptors and on human fat cell function; the drug inactivates the alpha-2 adrenergic receptors with a minor impact on beta adrenergic receptors and without noticeable alterations of fat cell function as assessed by preservation of beta adrenergic and Al-adenosine receptor-mediated lipolytic responses; and 4) a definition of the relationship existing between alpha-2 adrenergic receptor occupancy, inhibition of adenylate cyclase activity and antilipolysis with full and partial agonists.

Transcription (description) of alpha-1 in fat cell associated with adenocard, antagonist, obesity, agonist and potency

6) Confidence 0.13 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2566681 Disease Relevance 0.67 Pain Relevance 0.49

General Comments

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