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Context Info
Confidence 0.61
First Reported 1989
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 13
Total Number 16
Disease Relevance 6.58
Pain Relevance 8.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nr3c1) nucleus (Nr3c1) intracellular (Nr3c1)
DNA binding (Nr3c1) protein complex (Nr3c1) transcription factor binding (Nr3c1)
Anatomy Link Frequency
hypothalamus 1
pituitary 1
Gill 1
fibroblast 1
Nr3c1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 46 100.00 Very High Very High Very High
antagonist 43 100.00 Very High Very High Very High
Pain 6 100.00 Very High Very High Very High
neuralgia 2 100.00 Very High Very High Very High
anesthesia 2 100.00 Very High Very High Very High
Morphine 387 99.96 Very High Very High Very High
agonist 22 99.76 Very High Very High Very High
dexamethasone 128 99.44 Very High Very High Very High
allodynia 8 99.36 Very High Very High Very High
Neuropathic pain 41 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 56 99.36 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 5 99.30 Very High Very High Very High
Hyperalgesia 9 98.80 Very High Very High Very High
Targeted Disruption 16 98.28 Very High Very High Very High
Depression 44 98.00 Very High Very High Very High
Stress 26 97.52 Very High Very High Very High
Injury 31 96.84 Very High Very High Very High
Apoptosis 24 96.80 Very High Very High Very High
Hypertrophy 4 96.56 Very High Very High Very High
Cancer 39 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glucocorticoid receptor regulation: the effects of adrenalectomy, exogenous glucocorticoid, and stress on hepatic receptor number in male and female mice.
Regulation (regulation) of Glucocorticoid receptor associated with stress and anesthesia
1) Confidence 0.61 Published 1989 Journal Biochem. Med. Metab. Biol. Section Title Doc Link 2568122 Disease Relevance 0.24 Pain Relevance 0.10
Hyperactivity of HPA axis results probably from deregulation of glucocorticoid receptor function and impairment of the control mechanism of glucocorticoid secretion.
Regulation (deregulation) of glucocorticoid receptor associated with attention deficit hyperactivity disorder
2) Confidence 0.50 Published 2005 Journal Pharmacol Rep Section Abstract Doc Link 16129923 Disease Relevance 0.52 Pain Relevance 0.34
Effects of glucocorticoid receptor antagonists on allodynia and hyperalgesia in mouse model of neuropathic pain.
Regulation (Effects) of glucocorticoid receptor associated with neuralgia, hyperalgesia, allodynia, antagonist and neuropathic pain
3) Confidence 0.45 Published 2005 Journal Eur. J. Pharmacol. Section Title Doc Link 16256102 Disease Relevance 0.98 Pain Relevance 1.59
The glucocorticoid receptor antagonist RU-38486 (15 mg kg(-1) i.p.) did not affect morphine-induced straub reaction, whereas it was able to block the effects of dexamethasone on morphine-induced straub reaction.
Neg (not) Regulation (affect) of glucocorticoid receptor associated with antagonist, dexamethasone and morphine
4) Confidence 0.45 Published 2002 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 12162718 Disease Relevance 0 Pain Relevance 1.45
These results suggest that impaired glucocorticoid receptor function can affect hippocampal 5-HT2A receptor expression in transgenic mice and that this is not corrected by fluoxetine treatment.
Regulation (affect) of glucocorticoid receptor associated with targeted disruption and fluoxetine
5) Confidence 0.45 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11174015 Disease Relevance 0.81 Pain Relevance 0.41
The Nr3c1 probe set which encodes the GR was up-regulated 4-fold from day 3 to day 15 of micromass culture (Figure 1A, top panel).
Regulation (regulated) of Nr3c1
6) Confidence 0.41 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.21 Pain Relevance 0.20
The glucocorticoid receptor antagonist RU-38486 (15 mg/kg,i.p.) did not affect morphine-induced straub reaction, whereas it was able to block the effects of dexamethasone on morphine-induced straub reaction.
Neg (not) Regulation (affect) of glucocorticoid receptor associated with antagonist, dexamethasone and morphine
7) Confidence 0.34 Published 2007 Journal Recent patents on CNS drug discovery Section Abstract Doc Link 18221228 Disease Relevance 0 Pain Relevance 1.54
It is concluded that although glucocorticoids clearly regulate glucocorticoid receptor number, as demonstrated by adrenalectomy and the administration of steroids to adrenalectomized animals, the physiologic significance of this process is uncertain as receptor number does not appear to be changed by stimuli of adrenal glucocorticoids in the intact animal.
Regulation (regulate) of glucocorticoid receptor
8) Confidence 0.27 Published 1989 Journal Biochem. Med. Metab. Biol. Section Abstract Doc Link 2568122 Disease Relevance 0.23 Pain Relevance 0
Our further literature search yielded data that implicate the glucocorticoid receptor (GR) as a potential modulator of Tsc22d3 transcription [17].
Spec (implicate) Regulation (implicate) of glucocorticoid receptor
9) Confidence 0.08 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.63 Pain Relevance 0.34
Morphine effects on striatal transcriptome in mice

Global transcriptional analysis of mouse striata following acute and chronic exposure to morphine reveals multiple physiological factors which may affect opioid-related phenotypes and implicates a number of gene networks, including glucocorticoid receptor regulated genes, in the response to this opioid.


Regulation (regulated) of glucocorticoid receptor associated with opioid and morphine
10) Confidence 0.08 Published 2007 Journal Genome Biol Section Title Doc Link PMC2394777 Disease Relevance 0.32 Pain Relevance 1.02
Among these genes, we recently suggested that glucocorticoid receptor [10] and peripheral-type benzodiazepine receptor [11] are useful targets in the management of neuropathic pain.
Regulation (targets) of glucocorticoid receptor associated with neuropathic pain
11) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.56 Pain Relevance 0.69
The regulation of gene expression pattern B was somewhat similar to the effects of the glucocorticoid receptor (GR) agonist dexamethasone in the hypothalamus (P = 1.57 × 10-8) [47].
Regulation (effects) of glucocorticoid receptor in hypothalamus associated with agonist and dexamethasone
12) Confidence 0.06 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.08 Pain Relevance 0.29
The 5-HT7 receptor is involved in hippocampal function (Gill et al 2002), and has been implicated in the regulation of the glucocorticoid receptor (Laplante et al 2002).
Regulation (regulation) of glucocorticoid receptor in Gill
13) Confidence 0.04 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.55 Pain Relevance 0.28
The aim of the present study was to investigate effects of some classical and new antidepressants on functional activity of the glucocorticoid receceptor (GR) induced by low corticosterone concentration in mouse fibroblast cells stably transfected with mouse mammary tumor virus-chloramphenicol acetyltransferase plasmid (LMCAT cells).
Spec (investigate) Regulation (effects) of glucocorticoid receceptor in fibroblast associated with antidepressant and cancer
14) Confidence 0.03 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18441395 Disease Relevance 0.10 Pain Relevance 0.20
So far, there is no significant experience reported with the glucocorticoid receptor antagonist mifepristone (RU 486) in CD, and assessment of its efficacy in the absence of a biochemical marker is challenging.9 In a European retrospective study, clinical signs of hypercortisolism improved rapidly in three of four patients with CD treated with mifepristone but one developed hypertension and severe hypokalemia during the therapy.87


Therapy for the complications of CD

Neg (no) Regulation (reported) of glucocorticoid receptor associated with pressure and volume under development, antagonist and bartter syndrome
15) Confidence 0.03 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963160 Disease Relevance 0.54 Pain Relevance 0.19
Drug treatment has been targeted at the hypothalamic or pituitary level, at the adrenal gland, and also at the glucocorticoid receptor level.
Regulation (targeted) of glucocorticoid receptor in pituitary
16) Confidence 0.03 Published 2010 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2963160 Disease Relevance 0.55 Pain Relevance 0

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