INT267597

Context Info Confidence 0.03 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.24 Pain Relevance 1.10

extracellular space (IL10, TNF) extracellular region (IL10, TNF) intracellular (IL10, TNF) signal transduction (TNF) plasma membrane (TNF) extracellular matrix organization (TNF)

Anatomy Link Frequency macrophages 3 monocytes 1 IL10 (Homo sapiens) TNF (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 222 100.00 cytokine 126 100.00 Inflammatory mediators 48 5.00 chemokine 34 5.00 Inflammatory response 22 5.00 bradykinin 12 5.00 metalloproteinase 10 5.00 fibrosis 4 5.00 Pain 2 5.00 potassium channel 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 288 100.00 Infection 28 92.48 Otitis Media With Effusion 184 86.72 Otitis Media 268 84.88 Cholesteatoma 96 5.00 Adhesions 28 5.00 Edema 20 5.00 Hypersensitivity 18 5.00 Metaplasia 8 5.00 Rhinitis 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

IL-10, being the key anti-inflammatory cytokine, inhibits monocytes/macrophages and the production of TNF, IL-1, IL-6 and IL-8 (84).

IL-10 Negative_regulation (inhibits) of Gene_expression (production) of TNF in macrophages associated with inflammation and cytokine

1) Confidence 0.03 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 1.12 Pain Relevance 0.55

IL-10, being the key anti-inflammatory cytokine, inhibits monocytes/macrophages and the production of TNF, IL-1, IL-6 and IL-8 (84).

IL-10 Negative_regulation (inhibits) of in monocytes Gene_expression (production) of TNF in macrophages associated with inflammation and cytokine

2) Confidence 0.01 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 1.12 Pain Relevance 0.55

General Comments

This test has worked.