INT267666

Context Info Confidence 0.22 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.39 Pain Relevance 0.30

transport (CFTR) ATPase activity (CFTR) plasma membrane (CFTR) enzyme binding (CFTR) protein complex (CFTR) transmembrane transport (CFTR)

Anatomy Link Frequency nasal 2 CFTR (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 11 93.68 sodium channel 3 88.08 adenocard 11 76.16 antagonist 2 40.76 Potency 1 35.32 fibrosis 2 5.00 corticosteroid 1 5.00 Inflammation 1 5.00 local anesthetic 1 5.00

Disease Link Frequency Relevance Heat Nasal Polyps 19 99.68 Polyps 10 6.36 Pressure And Volume Under Development 3 5.00 Cystic Fibrosis 2 5.00 Sinusitis 2 5.00 Recurrence 2 5.00 INFLAMMATION 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The CFTR activator, genistein (24), did not induce a CFTR current, which may be attributed to an altered localization of CFTR in the nasal polyp (25).

Regulation (altered) of Localization (localization) of CFTR in nasal associated with nasal polyps

1) Confidence 0.22 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671790 Disease Relevance 0.39 Pain Relevance 0.30

General Comments

This test has worked.