INT26798

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Context Info
Confidence 0.61
First Reported 1983
Last Reported 2004
Negated 4
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.93
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Man2a2)
Anatomy Link Frequency
hypothalamus 6
dopamine neurons 4
vertebral arteries 2
cortex 1
hippocampus 1
Man2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 8 100.00 Very High Very High Very High
Hippocampus 4 98.48 Very High Very High Very High
Dopamine 18 98.00 Very High Very High Very High
Clonidine 14 97.12 Very High Very High Very High
Ventral tegmentum 4 92.32 High High
antidepressant 4 88.00 High High
Potency 2 83.68 Quite High
antagonist 1 78.92 Quite High
Disease Link Frequency Relevance Heat
Hypotension 7 100.00 Very High Very High Very High
Anxiety Disorder 14 99.66 Very High Very High Very High
Stress 8 99.28 Very High Very High Very High
Sleep Disorders 2 84.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, there was no change in alpha 2-adrenoceptor binding in the cortex, while increased binding was found in the hypothalamus.
Neg (no) Regulation (change) of alpha 2 Binding (binding) of in hypothalamus
1) Confidence 0.61 Published 1983 Journal Neuroscience Section Abstract Doc Link 6300728 Disease Relevance 0 Pain Relevance 0.18
We conclude that the anxiolytic-like actions of alpha-2 agonists are not due to binding to alpha-2 receptors on the stress-sensitive mesoprefrontal dopamine neurons.
Neg (not) Regulation (due) of alpha-2 Binding (binding) of in dopamine neurons associated with stress, dopamine, anxiety disorder and agonist
2) Confidence 0.45 Published 2004 Journal Brain Res. Section Abstract Doc Link 15494168 Disease Relevance 0.74 Pain Relevance 0.55
We conclude that the anxiolytic-like actions of alpha-2 agonists are not due to binding to alpha-2 receptors on the stress-sensitive mesoprefrontal dopamine neurons.
Neg (not) Regulation (due) of alpha-2 Binding (binding) of in dopamine neurons associated with stress, dopamine, anxiety disorder and agonist
3) Confidence 0.45 Published 2004 Journal Brain Res. Section Abstract Doc Link 15494168 Disease Relevance 0.75 Pain Relevance 0.60
The effects of ten once-daily injections of desmethylimipramine (10 mg/kg i.p.) on alpha 2- and beta-adrenoceptor binding were investigated in the rat cortex, hippocampus and hypothalamus. [3H]clonidine and [3H]dihydroalprenolol were used as ligands for alpha 2- and beta-adrenoceptors, respectively.
Regulation (effects) of alpha 2 Binding (binding) of in hypothalamus associated with hippocampus and clonidine
4) Confidence 0.45 Published 1983 Journal Neuroscience Section Abstract Doc Link 6300728 Disease Relevance 0 Pain Relevance 0.18
This view, however, appeared to be incorrect for the following reasons: (1) In radioligand binding studies urapidil did not show any affinity for alpha 2 adrenoceptors; and (2) the central hypotensive activity of urapidil, injected into feline vertebral arteries remained unaffected by the alpha 2-adrenoceptor-blocking agents yohimbine and rauwolscine, which are known to suppress the central hypotensive effect of clonidine.
Neg (unaffected) Regulation (unaffected) of alpha 2 Binding (affinity) of in vertebral arteries associated with hypotension and clonidine
5) Confidence 0.29 Published 1989 Journal Am. J. Cardiol. Section Abstract Doc Link 2569262 Disease Relevance 0.44 Pain Relevance 0.30
The effects of ten once-daily injections of desmethylimipramine (10 mg/kg i.p.) on alpha 2- and beta-adrenoceptor binding were investigated in the rat cortex, hippocampus and hypothalamus. [3H]clonidine and [3H]dihydroalprenolol were used as ligands for alpha 2- and beta-adrenoceptors, respectively.
Regulation (effects) of alpha 2 in hippocampus Binding (binding) of in hypothalamus associated with hippocampus and clonidine
6) Confidence 0.15 Published 1983 Journal Neuroscience Section Abstract Doc Link 6300728 Disease Relevance 0 Pain Relevance 0.18
The effects of ten once-daily injections of desmethylimipramine (10 mg/kg i.p.) on alpha 2- and beta-adrenoceptor binding were investigated in the rat cortex, hippocampus and hypothalamus. [3H]clonidine and [3H]dihydroalprenolol were used as ligands for alpha 2- and beta-adrenoceptors, respectively.
Regulation (effects) of alpha 2 in cortex Binding (binding) of in hypothalamus associated with hippocampus and clonidine
7) Confidence 0.15 Published 1983 Journal Neuroscience Section Abstract Doc Link 6300728 Disease Relevance 0 Pain Relevance 0.18

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