INT268365

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.56
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SMAD2) nucleoplasm (SMAD2) nucleus (SMAD2)
intracellular (SMAD2) DNA binding (SMAD2) transcription factor binding (SMAD2)
SMAD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
long-term potentiation 7 75.92 Quite High
nMDA receptor 2 69.64 Quite High
COX2 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 31 86.88 High High
Apoptosis 12 84.60 Quite High
Pancreatic Cancer 1 72.92 Quite High
Colorectal Cancer 50 67.68 Quite High
Familial Adenomatous Polyposis 48 42.12 Quite Low
Hyperplasia 15 41.52 Quite Low
Adenoma 33 31.12 Quite Low
Targeted Disruption 2 25.00 Low Low
Metastasis 2 12.16 Low Low
Syndrome 38 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It phosphorylates smad2/3, which consequently binds with smad4 to form an antitumorigenesis transcription factor.
smad2 Binding (binds) of
1) Confidence 0.47 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0.17
This causes phosphorylation of SMAD2 and SMAD3, two transcription factors that then bind to and activate SMAD4.
SMAD2 Binding (bind) of
2) Confidence 0.35 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.56 Pain Relevance 0

General Comments

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