INT268386

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.84
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARAF) protein modification process (ARAF) mitochondrion (ARAF)
cellular_component (ARAF)
ARAF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 1 99.68 Very High Very High Very High
Inflammation 2 89.44 High High
Kinase C 7 86.92 High High
Neuropathic pain 1 57.04 Quite High
Migraine 1 56.20 Quite High
Intracerebroventricular 1 46.12 Quite Low
IPN 1 43.88 Quite Low
Pain 3 40.04 Quite Low
Spinal cord 12 5.00 Very Low Very Low Very Low
addiction 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 3 99.68 Very High Very High Very High
Pancreatic Cancer 70 99.48 Very High Very High Very High
Cancer 96 98.44 Very High Very High Very High
Hypoxia 41 98.32 Very High Very High Very High
Infection 1 98.08 Very High Very High Very High
Stress 2 94.32 High High
Targeted Disruption 20 93.40 High High
Fatigue 2 88.44 High High
Pressure And Volume Under Development 2 87.96 High High
Neutropenia 1 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In their model, it was suggested that mutation of the k-ras proto-oncogene leading to activation of the oncogene as well as mutational inactivation of tumour suppressor genes existing on chromosomes 5q (APC), 7p (p53) and 18q (SMAD4) were the key initiators of colorectal carcinogenesis.
Positive_regulation (activation) of oncogene associated with cancer
1) Confidence 0.17 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.29 Pain Relevance 0
The Ras oncogene is mutated in about 90% of pancreatic cancers, leading to constitutive activation of the Ras-Raf-MAPK signal transduction pathway.
Positive_regulation (activation) of Ras-Raf-MAPK associated with pancreatic cancer
2) Confidence 0.10 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.21 Pain Relevance 0
Signaling through this pathway is often initiated by activation of membrane-localized receptors, leading to activation of the GTPase Ras, and subsequent activation of the MAPK kinase kinase Raf, the MAPK kinases MEK1/2 and the MAPKs Erk1/2 [11].
Positive_regulation (activation) of Raf
3) Confidence 0.05 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.90 Pain Relevance 0.24
Perturbation of Raf, MEK or ERK had similar effects on the functional markers with ERK being the most notable (Fig. 8, lanes 1, 2 and 3).
Positive_regulation (Perturbation) of Raf
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.48 Pain Relevance 0
Hypoxia/DHP-d can activate ERK MAPKs via pathways independent or dependent [30] of Ras and Raf activation.
Positive_regulation (activation) of Raf associated with hypoxia
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.52 Pain Relevance 0
Additionally, it has been proposed that PKs potentially function as mediators of the inflammatory response during testicular infections [20].
Positive_regulation (mediators) of PKs associated with inflammatory response and infection
6) Confidence 0.03 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.44 Pain Relevance 0.09

General Comments

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